Pendimethalin

Name: Pendimethalin
Brand: MedChemExpress
SKU: HY-B0862
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0862 Purity: 99.75%: FAQs
Data Sheet SDS COA Handling Instructions

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Pendimethalin is an orally active herbicide that controls annual grasses and certain broadleaf weeds. Pendimethalin induces Apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells.

For research use only. We do not sell to patients.

Pendimethalin Chemical Structure

CAS No. : 40487-42-1

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g	USD 80	In-stock	Estimated Time of Arrival: December 31
5 g	USD 200	In-stock	Estimated Time of Arrival: December 31
10 g	USD 300	In-stock	Estimated Time of Arrival: December 31
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pendimethalin:

Pendimethalin-d₅ Get quote
Pendimethalin (Standard) Get quote

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	IC₅₀	0.26 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	0.34 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	0.71 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	0.75 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.1 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	12.2 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	13.2 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	2.5 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	3.2 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	3.2 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	9.7 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay	[PMID: 20145086]

In Vitro

Pendimethalin (50 and 100 μM , 24 h) induces significant decreases of cell viability, cell cycle arrest, apoptosis, ER stress and autophagy and mitochondrial dysfunction in human vascular endothelial cells (HUVECs )^[2].
Pendimethalin (25-100 μM , 6 h) represses migration and tube formation by HUVECs^[2].
Pendimethalin (50-200 μM, 3 h) exhibits DNA damage in human lymphocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	HUVECs
Concentration:	50 and 100 μM
Incubation Time:	24 h
Result:	Decreased the cell viability of 57% and 73% at 50 and 100 μM in HUVECs.

Cell Cycle Analysis^[2]

Cell Line:	HUVECs
Concentration:	50 and 100 μM
Incubation Time:	24 h
Result:	Increased the proportion of cells in the G1 phase in HUVECs.

Apoptosis Analysis^[2]

Cell Line:	HUVECs
Concentration:	50 and 100 μM
Incubation Time:	24 h
Result:	Significantly increased proportions of necrotic cells in HUVECs.

In Vivo

Pendimethalin (12.5-50 mg/kg, oral gavage, daily for 14 days) exhibits DNA damage in rat bone-marrow cells, decreases the levels of GSH, CAT and increases the levels of LPO in rats^[3].
Pendimethalin (62.5-250 mg/kg, p.o., daily for 14 days) induces oxidative stress in the liver and kidney of rats as indicated by noticeable decrease in SOD, CAT, GSH and GST levels and elevated levels of TBARS and carbonyl contents leading to liver and kidney injury, which shows activated kupfer cells and leukocyte infltrations, large cytoplasmic vacuolization and dilatation in blood sinusoids^[4].
Pendimethalin (62.5-250 mg/kg, p.o., daily for 14 days) results in a manifest up regulation of anti-infammatory and apoptosis markers, TNF-α, IFN-γ, Bax and Caspases-3 as well as down-regulation of Bcl-2, and a signifcant up-regulation of mRNA expression of the TNF-α gene intensity in rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (140±10 g), 8–9 weeks^[2]
Dosage:	12.5-50 mg/kg
Administration:	oral gavage, daily for 14 days
Result:	Induced 1.6, 4.9, and 10.5-fold (p<0.05) increase in comet OTM value at 12.5, 25, and 50 mg/kg b w/day.

Molecular Weight

281.31

Formula

C₁₃H₁₉N₃O₄

CAS No.

40487-42-1

Appearance

Solid

Color

Orange to red

SMILES

O=[N+](C1=C(NC(CC)CC)C([N+]([O-])=O)=C(C)C(C)=C1)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (177.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5548 mL	17.7740 mL	35.5480 mL
5 mM	0.7110 mL	3.5548 mL	7.1096 mL
10 mM	0.3555 mL	1.7774 mL	3.5548 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (8.89 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.75%

Select Batch:

Data Sheet (281 KB) SDS (537 KB)

COA (252 KB) HNMR (244 KB) LCMS (269 KB)

Handling Instructions (2659 KB)

References

[1]. Martin Kočárek, et al. Effect of adjuvant on pendimethalin and dimethenamid-P behaviour in soil. J Hazard Mater. 2018 Jul 15;354:266-274. [Content Brief]

[2]. Lee HS, et al. Pendimethalin induces apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells. Food Chem Toxicol. 2022 Oct;168:113370. [Content Brief]

[3]. Ansari SM, et al. Pendimethalin induces oxidative stress, DNA damage, and mitochondrial dysfunction to trigger apoptosis in human lymphocytes and rat bone-marrow cells. Histochem Cell Biol. 2018 Feb;149(2):127-141. [Content Brief]

[4]. Ahmad MI, et al. Pendimethalin-induced oxidative stress, DNA damage and activation of anti-inflammatory and apoptotic markers in male rats. Sci Rep. 2018 Nov 20;8(1):17139. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5548 mL	17.7740 mL	35.5480 mL	88.8699 mL
	5 mM	0.7110 mL	3.5548 mL	7.1096 mL	17.7740 mL
	10 mM	0.3555 mL	1.7774 mL	3.5548 mL	8.8870 mL
	15 mM	0.2370 mL	1.1849 mL	2.3699 mL	5.9247 mL
	20 mM	0.1777 mL	0.8887 mL	1.7774 mL	4.4435 mL
	25 mM	0.1422 mL	0.7110 mL	1.4219 mL	3.5548 mL
	30 mM	0.1185 mL	0.5925 mL	1.1849 mL	2.9623 mL
	40 mM	0.0889 mL	0.4443 mL	0.8887 mL	2.2217 mL
	50 mM	0.0711 mL	0.3555 mL	0.7110 mL	1.7774 mL
	60 mM	0.0592 mL	0.2962 mL	0.5925 mL	1.4812 mL
	80 mM	0.0444 mL	0.2222 mL	0.4443 mL	1.1109 mL
	100 mM	0.0355 mL	0.1777 mL	0.3555 mL	0.8887 mL

Pendimethalin Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pendimethalin40487-42-1ApoptosisSODCaspaseBcl-2 FamilySuperoxide Dismutaseorally activegrassesbroadleaf weedsApoptoticmitochondrial dysfunctionhuman umbilical vein endothelial cellsInhibitorinhibitorinhibit

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Pendimethalin

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Pendimethalin Related Antibodies

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Complete Stock Solution Preparation Table

Pendimethalin Related Classifications

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