2. Apoptosis PROTAC
  3. Bcl-2 Family Molecular Glues
  4. CCT369260

CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM.

For research use only. We do not sell to patients.

CCT369260 Chemical Structure

CCT369260 Chemical Structure

CAS No. : 2647503-57-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 504 In-stock
Solution
10 mM * 1 mL in DMSO USD 504 In-stock
Solid
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CCT369260:

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  • Biological Activity

  • Purity & Documentation

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Description

CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM[1].

IC50 & Target

IC50: 520 nM (BCL6)[1].
Cellular Effect
Cell Line Type Value Description References
OCI-Ly1 GI50
0.035 μM
Compound: 1; CCT369260
Antiproliferative activity agianst human OCI-LY1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
Antiproliferative activity agianst human OCI-LY1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
[PMID: 32275432]
OCI-Ly3 GI50
1.6 μM
Compound: 1; CCT369260
Antiproliferative activity agianst human OCI-LY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
Antiproliferative activity agianst human OCI-LY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
[PMID: 32275432]
SUD4 GI50
0.092 μM
Compound: 1; CCT369260
Antiproliferative activity agianst human SUDHL4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
Antiproliferative activity agianst human SUDHL4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
[PMID: 32275432]
In Vivo

CCT369260 (compound 1, 15 mg/kg, po, single dose) significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OCI-Ly1 DLBCL xenograft model (female SCID mice)[1].
Dosage: 15 mg/kg.
Administration: PO, single dose.
Result: Decreased the levels of BCL6 in the tumor observed up to 10 h after administration.
Animal Model: Female Balb/C mice[1].
Dosage: 1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis).
Administration: IV and PO
Result: Demonstrated moderate clearance (CL 20 mL min−1 kg−1) with mean oral bioavailability of 54%.
Molecular Weight

508.99

Formula

C24H31ClF2N6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCC(C)(O)C)C2=CC(NC3=NC(N4C[C@@H](C)C(F)(F)[C@@H](C)C4)=NC=C3Cl)=CC=C2N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (589.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9647 mL 9.8234 mL 19.6468 mL
5 mM 0.3929 mL 1.9647 mL 3.9294 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9647 mL 9.8234 mL 19.6468 mL 49.1169 mL
5 mM 0.3929 mL 1.9647 mL 3.9294 mL 9.8234 mL
10 mM 0.1965 mL 0.9823 mL 1.9647 mL 4.9117 mL
15 mM 0.1310 mL 0.6549 mL 1.3098 mL 3.2745 mL
20 mM 0.0982 mL 0.4912 mL 0.9823 mL 2.4558 mL
25 mM 0.0786 mL 0.3929 mL 0.7859 mL 1.9647 mL
30 mM 0.0655 mL 0.3274 mL 0.6549 mL 1.6372 mL
40 mM 0.0491 mL 0.2456 mL 0.4912 mL 1.2279 mL
50 mM 0.0393 mL 0.1965 mL 0.3929 mL 0.9823 mL
60 mM 0.0327 mL 0.1637 mL 0.3274 mL 0.8186 mL
80 mM 0.0246 mL 0.1228 mL 0.2456 mL 0.6140 mL
100 mM 0.0196 mL 0.0982 mL 0.1965 mL 0.4912 mL
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CCT369260 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT3692602647503-57-7CCT 369260CCT-369260Bcl-2 FamilyMolecular GluesInhibitorinhibitorinhibit

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