Calmodulin

CaM; Calcium-modulated protein

Calmodulin (CaM), the member of EF-hand proteins superfamily, is a highly conserved eukaryotic Ca²⁺ sensor protein. Upon cellular stimulation, different mechanisms lead to transient intracellular increases in Ca²⁺ concentrations that initiate different protein activities. Most proteins are devoid of Ca²⁺ binding sites, requiring a mediator to respond to this cation. The ability to transmit conformational changes to a large and diverse array of proteins in response to Ca²⁺ oscillations, coordinating the activity of hundreds of proteins, makes calmodulin the most important Ca²⁺ signal transducer in eukaryotic cells. When Ca²⁺ binds to calmodulin it forms the Ca²⁺/calmodulin complex which then interacts with other proteins in the cell. These proteins are enzymes and effector proteins involved in a variety of cellular and physiological processes. The Ca²⁺/calmodulin complex can also regulate processes directly.

Calmodulin Related Products (38)
Antibodies (4)

By Effects:	Inhibitors (14) Agonists (2) Antagonists (19)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-100912

W-7 hydrochloride	Antagonist	99.96%
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor activity.

HY-103319

Calmidazolium chloride	Antagonist	99.69%
Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC₅₀s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to calmodulin with a K_d of 3 nM.

HY-D0987

Stains-All		99.91%
Stains-All, a cationic carbocyanine dye, is a convenient probe to study the structural features of the individual calcium-binding sites of calmodulin (CaM) and related calcium-binding proteins (CaBP).

HY-P1076A

CALP2 TFA	Antagonist	99.79%
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages.

HY-P1077A

CALP1 TFA	Agonist	98.30%
CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity.

HY-105118

Zaldaride	Inhibitor
Zaldaride (CGS-9343B free base) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC₅₀ of 3.3 nM. Zaldaride prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na⁺, Ca²⁺ and K⁺ currents in PC12 cells and inhibits nAChR.

HY-124176

L-6355	Antagonist
L-6355 is an Amiodarone (HY-14187) related compound, which inhibits Ca²⁺/calmodulin activated cyclic nucleotide phosphodiesterase with an IC₅₀ value of 0.65 μM. L-6355 is promising for research of antiarrhythmic and antianginal agent.

HY-118242

RU 45144	Antagonist
RU 45144 is an anti-estrogen compound that has the activity of antagonizing the binding of estrogen receptors to calmodulin. RU 45144 can inhibit the binding of estrogen receptors to calmodulin, and its effect is similar to that of tamoxifen. Its anti-estrogen effect may be related to specific side chains in the molecular structure, and the steroid skeleton may be involved in its anti-proliferative activity.

HY-100913

W-7 isomer hydrochloride	Antagonist	99.65%
W-7 isomer hydrochloride is an isomer of W-7 hydrochloride (HY-100912). W-7 hydrochloride is a selective calmodulin antagonist.

HY-N7503

Psoralenoside	Inhibitor	99.84%
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia. Psoralenoside exhibits high binding affinities against histaminergic H₁, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol). Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.

HY-105118A

Zaldaride maleate	Antagonist	≥98.0%
Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC₅₀ of 3.3 nM. Zaldaride maleate prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na⁺, Ca²⁺ and K⁺ currents in PC12 cells and inhibits nAChR.

HY-100911

W-5 hydrochloride	Antagonist	99.93%
W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC₅₀ value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912).

HY-N10772

Albanin A	Inhibitor
Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca²⁺/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.

HY-115745

Calmodulin antagonist-1	Antagonist	≥98.0%
Calmodulin antagonist-1 (A-5) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca²⁺-phosphodiesterase (PDE) (IC₅₀=66 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca²⁺-PDE (IC₅₀=560 μM) in a competitive fashion with respect to cyclic GMP.

HY-P2471

Neurogranin (48-76), mouse	Inhibitor
Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca²⁺-CaM) pathway.

HY-100914

A-7 hydrochloride	Antagonist	99.09%
A-7 hydrochloride (Ophobolin A) is a calmodulin antagonist and can be used for the research of cancer.

HY-100263

Metofenazate	Inhibitor
Metofenazate is a selective calmodulin inhibitor.

HY-133782

Fluphenazine-N-2-chloroethane hydrochloride	Antagonist
Fluphenazine-N-2-chloroethane (SKF-7171A) hydrochloride is a potent irreversible calmodulin antagonist.

HY-P1076

CALP2	Antagonist
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages.

HY-N10198

Acremonidin A	Inhibitor
Acremonidin A is a potent calmodulin (CaM) inhibitor found in Purpureocillium lilacinum. Acremonidin A binds to the human calmodulin (hCaM) biosensor hCaM M124C-mBBr, with K_d of 19.40 nM.

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Calmodulin

Calmodulin Related Products (38)

Antibodies (4)

Calmodulin Related Products (38):