2. Signaling Pathways
  3. Cytoskeleton
  4. Dynamin

Dynamin

Dynamin

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Dynamins are large superfamily GTPase proteins that are involved in various cellular processes including budding of transport vesicles, division of organelles, cytokinesis, and pathogen resistance. Dynamins are involved in scission (cleavage of the vesicle from the parent membrane) of nascent vesicles from parent membranes in eukaryotic cells. Dynamins interact directly with the lipid bilayer at the necks of clathrin-coated pits to sever and release coated vesicles. Dynamins contain five domains, including GTPase domain, middle domain, PH domain, GTPase effector domain (GED), and proline rich domain (PRD), while the dynamin-related proteins (DRPs) lack one or more of these domains or have additional domains. Dynamins and DRPs participate in a wide variety of cellular processes, including budding mitochondrial fission (mammalian Dlp1 and Saccharomyces cerevisiae Dnm1) and fusion (mammalian OPA1, S.cerevisiae Mgm1 and Schizosaccharomycespombe Msp1), vacuolar fission (S. cerevisiae Vps1), interferon-induced anti-viral protection (fish Mx proteins), plant cell cytokinesis and membrane fission (Arabidopsis thalianaDRP proteins), as well as pathogen resistance.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W013158
    Trimethyloctadecylammonium bromide
    		Inhibitor ≥98.0%
    Trimethyloctadecylammonium bromide is an inhibitor of dynamin, with an IC50 value of 1.9 μM for dynamin I. Trimethyloctadecylammonium bromide exhibits antibacterial activity against Staphylococcus aureus.
    Trimethyloctadecylammonium bromide
  • HY-P1369
    DynaMin inhibitory peptide, myristoylated
    		Inhibitor 99.81%
    DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis.
    DynaMin inhibitory peptide, myristoylated
  • HY-152086
    DRP1i27
    		Inhibitor 98.73%
    DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury.
    DRP1i27
  • HY-125222
    Drp1-IN-1
    		Inhibitor 98.02%
    Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC50 of 0.91 μM.
    Drp1-IN-1
  • HY-152217
    Clathrin-IN-2
    		Inhibitor
    Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC50 value of 7.7 μM.
    Clathrin-IN-2
  • HY-132583
    IONIS-DNM2-2.5Rx
    		Inhibitor
    IONIS-DNM2-2.5Rx (DYM101) is an antisense agent targeting dynamin 2. IONIS-DNM2-2.5Rx has the potential for the research of centronuclear myopathy (CNM).
    IONIS-DNM2-2.5Rx
  • HY-152216
    Dynamin IN-2
    		Inhibitor
    Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM.
    Dynamin IN-2
  • HY-118244
    Clathrin-IN-3
    		Inhibitor
    Clathrin-IN-3 (Compound 25) is a Clathrin inhibitor (IC50: 6.9 μM). Clathrin-IN-3 potenly inhibits clathrin terminal domain-amphiphysin PPI.
    Clathrin-IN-3
  • HY-P1369A
    DynaMin inhibitory peptide, myristoylated TFA
    		Inhibitor
    DynaMin inhibitory peptide, myristoylated TFA is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide that prevents endocytosis.
    DynaMin inhibitory peptide, myristoylated TFA
  • HY-N0703R
    Schaftoside (Standard)
    		Inhibitor
    Schaftoside (Standard) is the analytical standard of Schaftoside. This product is intended for research and analytical applications. Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
    Schaftoside (Standard)
  • HY-132583A
    IONIS-DNM2-2.5Rx sodium
    		Inhibitor
    IONIS-DNM2-2.5Rx sodium is an antisense agent targeting dynamin 2, and has the potential for the research of centronuclear myopathy (CNM).
    IONIS-DNM2-2.5Rx sodium
  • HY-122564
    Pyrimidyn 7
    		Inhibitor
    Pyrimidyn 7 is an inhibitor of dynamin I/II with IC50 values of 1.1 μM and 1.8 μM, respectively. Pyrimidyn 7 competitively inhibits the interactions between GTP and phospholipids with dynamin I. Additionally, Pyrimidyn 7 reversibly inhibits clathrin-mediated endocytosis (CME) of transferrin and epidermal growth factor (EGF) in various non-neuronal cell linecell[1.
    Pyrimidyn 7
  • HY-P1083A
    Dynamin inhibitory peptide TFA
    		Inhibitor
    Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D3 effect on GABAA receptors.
    Dynamin inhibitory peptide TFA
  • HY-164290
    Rhodady C10
    		Inhibitor
    Rhodady C10 (Compound C10) is a dynamin I GTPase inhibitor. Rhodady C10 blocks receptor-mediated endocytosis (IC50: 7 μM). Dynamin is involved in clathrin-independent endocytosis, phagocytosis, and caveolae internalization.
    Rhodady C10
  • HY-123572
    Bis-T-23
    Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD).
    Bis-T-23
  • HY-P991105
    Anti-Clathrin Heavy Chain Antibody
    		Inhibitor
    Anti-Clathrin Heavy Chain Antibody is a human antibody expressed in CHO cells, targeting Clathrin Heavy Chain. Anti-Clathrin Heavy Chain Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-Clathrin Heavy Chain Antibody
Cat. No. Product Name / Synonyms Application Reactivity