Dynamin Inhibitor

Dynamin Inhibitors (31):

Cat. No.	Product Name	Effect	Purity

HY-15886

Mdivi-1	Inhibitor	99.96%
Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.

HY-15304

Dynasore	Inhibitor	99.66%
Dynasore is a cell-permeable dynamin inhibitor with an IC₅₀ of 15 μM. Dynasore blocks cell migration.

HY-13863

Hydroxy-Dynasore	Inhibitor	99.11%
Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC₅₀ values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC₅₀ of 5.7 μM.

HY-N0703

Schaftoside	Inhibitor	99.67%
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.

HY-131683

ES9-17	Inhibitor	99.87%
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings.

HY-P6437

Drp1 peptide inhibitor P110	Inhibitor
Drp1 peptide inhibitor P110 (Compound P110) is a selective Drp1 peptide inhibitor with neuroprotective properties. Drp1 peptide inhibitor P110 can inhibit the activation of Drp1, prevent MPTP-induced Drp1 mitochondrial translocation, and alleviate MPTP-induced dopaminergic neuron loss, dopaminergic nerve terminal damage, and behavioral deficits, and can be used in the study of Alzheimer's disease. Additionally, Drp1 peptide inhibitor P110 can reduce mitochondrial damage and organ injury in animal models of Huntington's disease, cerebral ischemic injury, and myocardial infarction.

HY-131037

MB-0223	Inhibitor
MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC₅₀=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC₅₀>100 μM).

HY-107545

Dynole 34-2	Inhibitor	98.16%
Dynole 34-2 is a dynamin GTPase inhibitor (IC₅₀s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME).

HY-145080

Dynole 2−24	Inhibitor	98.13%
Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC₅₀=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC_₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis

HY-P10368

P110 heptapeptide	Inhibitor	99.84%
P110 heptapeptide, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1.

HY-161119

Drpitor1a	Inhibitor
Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer^[1]

HY-131873

Dynapyrazole-A	Inhibitor	98.41%
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity.

HY-152215

Dynamin IN-1	Inhibitor	99.89%
Dynamin IN-1 is a potent dynamin inhibitor with an IC₅₀ value of 1.0 µM.

HY-P2280

TAT-P110	Inhibitor	99.26%
TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1.

HY-P1083

Dynamin inhibitory peptide	Inhibitor
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors.

HY-P1369

DynaMin inhibitory peptide, myristoylated	Inhibitor	99.81%
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis.

HY-152218

Clathrin-IN-4	Inhibitor
Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC₅₀ of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC₅₀ of 9.1 μM.

HY-152086

DRP1i27	Inhibitor	98.73%
DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury.

HY-125222

Drp1-IN-1	Inhibitor	98.02%
Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC₅₀ of 0.91 μM.

HY-164566

POSH-IN-2	Inhibitor	98.88%
POSH-IN-2 (MIDI), a mitochondrial division inhibitor, is a DRP1 inhibitor that potently blocks mitochondrial fragmentation induced by cellular stresses and genetic mitochondrial lesions. POSH-IN-2 covalently interacts with DRP1-C367 to target DRP1 interaction with multiple receptors.

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