IKK

IκB kinase; I kappa B kinase

IKK

Related Products

IKK is a complex composed of three subunits: IKKα, IKKβ, and IKKγ (also called NEMO). The complex is the signal integration hub for NF-κB activation. It integrates signals from all NF-κB activating stimuli to catalyze the phosphorylation of various IκB and NF-κB proteins, as well as of other substrates. The human IKK family has four members, the IKKs IKK-alpha and IKK-beta, and the IKK-related kinases TBK1 and IKK-epsilon.

Two members, IKKα and IKKβ, the so-called canonical members, phosphoryate IκBα, leading to activation of the transcription factor NF-κB, which controls the expression of many immune and inflammatory genes. The IKK-related proteins TBK-1 and IKK-epsilon have a different substrate--IRF3--which regulates a different set of genes, the products of which include Type I interferons. IKKs are a therapeutic target due to their crucial roles in various biological processes, including the immune response, the stress response, and tumor development.

IKK Isoform Specific Products:

IKK Isoform Comparison

IKK Related Products (109)
Antibodies (15)
IKK Isoform Comparison

By Effects:	Control (1) Inhibitors (102) Degrader (1) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-139833

Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks the phosphorylation of I kappa b kinase α/β (IKKα/β), IκBα, and nuclear factor kB p65 (NF-κB p65) which is a key controller of inflammation, thereby showing anti-inflammatory potential.

HY-136392

IKK-IN-3	Inhibitor
IKK-IN-3 is a potent and selective IkappaB kinase 2 (IKK2 or IKKβ) inhibitor, with IC₅₀s of 19 and 400 nM for IKK2 and IKK1 (or IKKα), respectively.

HY-114730

CGA-JK3	Inhibitor
CGA-JK3 is CGA-JK3 is an ATP-competitive inhibitor of IKKβ-catalyzed kinase activity. CGA-JK3 inhibits IκBα phosphorylation in LPS (HY-D1056) - induced RAW 264.7 cells.

HY-164480

GTCpFE	Inhibitor
GTCpFE inhibits IKKα/β in the NF-κB pathway with anti-inflammatory activities and blocks p65 nuclear entry, which consists of Dimethyl fumarate (DMF) (HY-17363) linked to Aspirin (ASA) (HY-14654). GTCpFE exhibits selective anti-cancer stem-like cell (CSC) activity by reducing mammosphere growth and the CD44⁺ CD24^- immunophenotype. GTCpFE inhibits breast cancer stem cells, an important NFκB- and PGE2-dependent phenotype in aggressive cancers.

HY-U00457

TBK1/IKKε-IN-1	Inhibitor
TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC₅₀s of <100 nM.

HY-N0547R

Nomilin (Standard)	Inhibitor
Nomilin (Standard) is the analytical standard of Nomilin. This product is intended for research and analytical applications. Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .

HY-N0476R

Wilforlide A (Standard)	Inhibitor
Wilforlide A (Standard) is the analytical standard of Wilforlide A. This product is intended for research and analytical applications. Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects.

HY-B0713R

Amlexanox (Standard)	Inhibitor
Amlexanox (Standard) is the analytical standard of Amlexanox. This product is intended for research and analytical applications. Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC₅₀ of approximately 1-2 μM.

HY-13295R

Vinpocetine (Standard)	Inhibitor
Vinpocetine (Standard) is the analytical standard of Vinpocetine. This product is intended for research and analytical applications. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.

Resveratrol		IKKβ, IC₅₀: 1 μM				99.94%
BX795				IKKε, IC₅₀: 41 nM	TBK1, IC₅₀: 6 nM	99.84%
GSK8612					TBK1, pIC₅₀: 6.8	99.62%
Amlexanox				IKKε, IC₅₀: 1-2 μM	TBK1, IC₅₀: 1-2 μM	99.70%
Verproside			IKK
TPCA-1		IKK-2, IC₅₀: 17.9 nM				99.66%
MRT67307				IKKε, IC₅₀: 160 nM (at 0.1 mM ATP)	TBK1, IC₅₀: 19 nM (at 0.1 mM ATP)	99.44%
IMD-0354		IKKβ				99.26%
BMS-345541	IKK-1, IC₅₀: 4 μM	IKK-2, IC₅₀: 0.3 μM				99.86%
IKK 16	IKK1, IC₅₀: 200 nM	IKK2, IC₅₀: 40 nM	IKK, IC₅₀: 70 nM			99.88%
BAY-985				IKKε, IC₅₀: 2 nM	TBK1, IC₅₀: 2 nM (low ATP) TBK1, IC₅₀: 30 nM (high ATP)	99.88%
BMS-345541 hydrochloride	IKK-1, IC₅₀: 4 μM	IKK-2, IC₅₀: 0.3 μM				99.90%
Vinpocetine			IKK, IC₅₀: 17.17 μM			99.57%
MLN120B		IKKβ, IC₅₀: 60 nM				99.76%
ACHP Hydrochloride	IKK-α, IC₅₀: 250 nM	IKK-β, IC₅₀: 8.5 nM				99.54%
Resveratrol (Standard)		IKKβ				99.73%
PS-1145			IKK, IC₅₀: 88 nM			99.88%
HOIPIN-1	IKK-α	IKK-β
Peramivir	IKK-α					99.32%
TBK1-IN-1					TBK1, IC₅₀: 22.4 nM	99.91%
SC-514		IKK-2, IC₅₀: 11.2 μM				99.89%
BAY32-5915	IKK-α, IC₅₀: 60 nM					99.80%
Plantainoside D		IKK-β				99.92%
BI605906		IKKβ, IC₅₀: 380 nM (at 0.1 mM ATP)				99.67%
TBK1/IKKε-IN-2				IKKε, IC₅₀: 3.9 nM (at 10 μM ATP)	TBK1, IC₅₀: 0.6 nM (at 5 μM ATP)	98.09%
LY2409881 trihydrochloride		IKK2, IC₅₀: 30 nM				98.14%
Ertiprotafib		IKK-β, IC₅₀: 400 nM				98.86%
Oxaprozin			IKK			99.95%
IKK 16 hydrochloride	IKK1, IC₅₀: 200 nM	IKK2, IC₅₀: 40 nM	IKK, IC₅₀: 70 nM			99.95%
Bay 65-1942 hydrochloride		IKKβ				99.39%
INH14	IKKα, IC₅₀: 8.97 μM	IKKβ, IC₅₀: 3.59 μM				≥98.0%
TBK1/IKKε-IN-4				IKKε, IC₅₀: 59 nM	TBK1, IC₅₀: 13 nM	99.42%
HPN-01	IKK-α, pIC₅₀: 6.4	IKK-β, pIC₅₀: 7.0		IKK-ε, pIC₅₀: <4.8		98.61%
GSK319347A		IKK2, IC₅₀: 790 nM		IKK-ε, IC₅₀: 469 nM	TBK1, IC₅₀: 93 nM	99.25%
SU1261	IKK-α	IKK-β				99.13%
PHA 408		IKK-2				≥98.0%
IKK-IN-1			IKK
IMD-0560		IKKβ				98.73%
AZD3264		IKK2				99.46%
BOT-64		IKKβ, IC₅₀: 1 μM				99.77%
IKK2-IN-4		IKK-2, IC₅₀: 25 nM				99.89%
(Rac)-PF-184 hydrate		IKK-2, IC₅₀: 37 nM				≥98.0%
MRT67307 hydrochloride				IKKε, IC₅₀: 160 nM (at 0.1 mM ATP)	TBK1, IC₅₀: 19 nM (at 0.1 mM ATP)
BMS-066		IKKβ, IC₅₀: 9 nM				99.09%
IKK2-IN-3		IKK2, IC₅₀: 0.075 μM				≥98.0%
IKKβ-IN-4		IKKβ, IC₅₀: 1.9 μM				99.94%
Bay 65-1942 free base		IKKβ
LY2409881		IKK2, IC₅₀: 30 nM
(Rac)-BAY-985					TBK1, IC₅₀: 1.5 nM
ACHP	IKK-α, IC₅₀: 250 nM	IKK-β, IC₅₀: 8.5 nM
IKKβ-IN-3		IKKβ, IC₅₀: 30.4 nM
IKKβ-IN-1		IKK-β, IC₅₀: 0.2
Oxaprozin potassium			IKK
Lucidone			IKK
(Rac)-PF-184		IKK-2, IC₅₀: 37 nM
Resveratrol (GMP)		IKKβ, IC₅₀: 1
PF-184		IKK-2, IC₅₀: 37 nM
TBK1/IKKε-IN-1				IKKε, IC₅₀: 100 nM	TBK1, IC₅₀: 100 nM

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IKK

IKK

IKK Isoform Specific Products:

IKK Isoform Specific Products:

IKK Related Products (109)

Antibodies (15)

IKK Isoform Comparison

IKK Related Products (109):