2. NF-κB
  3. IKK NF-κB
  4. SU1261

SU1261 is an IKK inhibitor with Ki values of 10 nM and 680 nM for IKKα and IKKβ, respectively. SU1261 can inhibit non-canonical NF-κB signaling in U2OS osteosarcoma cells.

For research use only. We do not sell to patients.

SU1261 Chemical Structure

SU1261 Chemical Structure

CAS No. : 3061890-98-7

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Based on 1 publication(s) in Google Scholar

SU1261 Related Antibodies

Top Publications Citing Use of Products

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IKK-α IKK-β IKK IKKε TBK1

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

SU1261 is an IKK inhibitor with Ki values of 10 nM and 680 nM for IKKα and IKKβ, respectively. SU1261 can inhibit non-canonical NF-κB signaling in U2OS osteosarcoma cells[1].
IC50 & Target

IKK-α

 

IKK-β

 

Molecular Weight

431.49

Formula

C27H21N5O
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

NC1=NNC(C=C2)=C1C=C2C(C=CN=C3N4)=C3C=C4C5=CC=CC(OCC6=CC=CC=C6)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (231.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3176 mL 11.5878 mL 23.1755 mL
5 mM 0.4635 mL 2.3176 mL 4.6351 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3176 mL 11.5878 mL 23.1755 mL 57.9388 mL
5 mM 0.4635 mL 2.3176 mL 4.6351 mL 11.5878 mL
10 mM 0.2318 mL 1.1588 mL 2.3176 mL 5.7939 mL
15 mM 0.1545 mL 0.7725 mL 1.5450 mL 3.8626 mL
20 mM 0.1159 mL 0.5794 mL 1.1588 mL 2.8969 mL
25 mM 0.0927 mL 0.4635 mL 0.9270 mL 2.3176 mL
30 mM 0.0773 mL 0.3863 mL 0.7725 mL 1.9313 mL
40 mM 0.0579 mL 0.2897 mL 0.5794 mL 1.4485 mL
50 mM 0.0464 mL 0.2318 mL 0.4635 mL 1.1588 mL
60 mM 0.0386 mL 0.1931 mL 0.3863 mL 0.9656 mL
80 mM 0.0290 mL 0.1448 mL 0.2897 mL 0.7242 mL
100 mM 0.0232 mL 0.1159 mL 0.2318 mL 0.5794 mL
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SU1261 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SU12613061890-98-7SU 1261SU-1261IKKNF-κBIκB kinaseI kappa B kinase Nuclear factor-κBNuclear factor-kappaBU2OSInhibitorinhibitorinhibit

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