2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Microtubule/Tubulin

Microtubule/Tubulin

Microtubule/Tubulin

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Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155459
    Tubulin polymerization-IN-57
    		Inhibitor
    Tubulin polymerization-IN-57 (compound 5a) is a tubulin inhibitor and is an α-naphthoxy-substituted carbendazim (HY-13582) derivative. Tubulin polymerization-IN-57 induces mitotic arrest and inhibits cancer cell proliferation.
    Tubulin polymerization-IN-57
  • HY-120027
    Kribb3
    		Inhibitor
    Kribb3 is an inhibitor for microtubule. KRIBB3 inhibits the proliferation of cancer cells with GI50 of 0.2-2.5 μM, arrests cell cycle at G2/M phase, and induces apoptosis in HCT-116. Kribb3 exhibits antitumor activity in mouse models.
    Kribb3
  • HY-78903A
    Monomethyl auristatin E intermediate-10
    		Control
    Monomethyl auristatin E intermediate-10 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs).
    Monomethyl auristatin E intermediate-10
  • HY-107492
    Ethaboxam
    		Inhibitor
    Ethaboxam is a β-tubulin inhibitor that can be used as anti-oomycete fungicide.
    Ethaboxam
  • HY-168326
    Antiproliferative agent-64
    		Inhibitor
    Antiproliferative agent-64 (Compound 76) is an inhibitor for eukaryotic translation initiation factor 4E (eIF4E), that block the secondary structure of mRNA, thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5' untranslated region (5'UTR) of c-Myc (c-myc 5'UTR) with an EC50 of 1.2 nM, inhibits 5'UTR encoding tubulin (tub 5'UTR) with an EC50 of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC50 of 7 nM.
    Antiproliferative agent-64
  • HY-W470415
    Alfalone
    		Inhibitor
    Alfalone (compound 9ia) is an antimitotic agent. Alfalone causes cleavage arrest and initiates the formation of tuberculate eggs.
    Alfalone
  • HY-79128S1
    Fmoc-L-Lys (Boc)-OH-13C6,15N2
    		Inhibitor
    Fmoc-L-Lys (Boc)-OH-13C6,15N2 is a 15N-labeled and 13C-labled Triclabendazole.
    Fmoc-L-Lys (Boc)-OH-<sup>13</sup>C<sub>6</sub>,<sup>15</sup>N<sub>2</sub>
  • HY-B0413R
    Fenbendazole (Standard)
    		Inhibitor
    Fenbendazole (Standard) is the analytical standard of Fenbendazole. This product is intended for research and analytical applications. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53.
    Fenbendazole (Standard)
  • HY-12053AR
    Vinorelbine (ditartrate) (Standard)
    		Inhibitor
    Vinorelbine (ditartrate) (Standard) is the analytical standard of Vinorelbine (ditartrate). This product is intended for research and analytical applications. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
    Vinorelbine (ditartrate) (Standard)
  • HY-43147
    Monomethyl auristatin E intermediate-4
    		Control
    Monomethyl auristatin E intermediate-4 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs).
    Monomethyl auristatin E intermediate-4
  • HY-137866
    Tubulin inhibitor 9
    		Inhibitor
    Tubulin inhibitor 9 (compound 7) is a tubulin (Microtubule/Tubulin)Inhibitors with anticancer activity (MDA-MB 231, IC50=0.9 nM).
    Tubulin inhibitor 9
  • HY-169882
    Tubulin inhibitor 49
    		Inhibitor
    Tubulin inhibitor 49 (Compound 18) is an inhibitor for tubulin polymerization with an IC50 of 48 μM. Tubulin inhibitor 49 disrupts the cell microtubule network, arrests the cell cycle at G2 phase, and exhibits cytotoxicity (IC50=8.8 μM in HeLa cell).
    Tubulin inhibitor 49
  • HY-110090
    UA62784
    		Inhibitor
    UA62784 is a microtubule polymerization inhibitor that interacts with tubulin dimers. UA62784 is a novel specific inhibitor of centromere protein E (CENP-E) kinesin. UA62784 can be used for the study of pancreatic cancer.
    UA62784
  • HY-121989
    cis-Trismethoxy resveratrol
    		Inhibitor ≥98.0%
    Cis-trismethoxy resveratrol is a potent anti-mitotic reagent.Cis-trismethoxy resveratrol inhibits tubulin polymerization with an IC50 value of 4 μM.
    cis-Trismethoxy resveratrol
  • HY-79255
    Fmoc-MMAF-OMe
    		Inhibitor
    Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor with an Fmoc protecting group. The active ingredient of Fmoc-MMAF-OMe, MMAF (HY-15579), is the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs).
    Fmoc-MMAF-OMe
  • HY-122249
    MT-7
    		Inhibitor
    MT-7 is a potent mitotic inhibitor. MT-7 shows antiproliferative activity. MT-7 induces cell cycle arrest at G2/M phase. MT-7 induces specific, reversible mitotic arrest and inhibits the polymerization of cellular microtubules.
    MT-7
  • HY-41070
    Taltobulin intermediate-8
    		Control
    Taltobulin intermediate-8 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis.
    Taltobulin intermediate-8
  • HY-P10589
    Phomopsinamine A
    		Inhibitor
    Phomopsinamine A is a derivative of Phomopsin A (HY-N6793). Phomopsinamine A is an inhibitor for tubulin polymerization with IC50 of 0.53 μM. Phomopsinamine A inhibits the binding of Vinblastine (HY-13780) to tubulin (IC50 =0.56 μM), promotes the the binding of Colchicine (HY-16569) to tubulin (IC50 =0.32 μM).
    Phomopsinamine A
  • HY-W011996
    2-Methylthiophenothiazine
    		Inhibitor ≥99.0%
    2-Methylthiophenothiazine (compound 17) is a precursor of tubulin inhibitor with potential anticancer activity and can inhibit tubulin aggregation.
    2-Methylthiophenothiazine
  • HY-117841
    T900607
    		Inhibitor
    T900607 is an anti-tumor agent and targets microtubule polymerization.
    T900607
Cat. No. Product Name / Synonyms Application Reactivity