Fmoc-MMAF-OMe

Cat. No.: HY-79255: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor with an Fmoc protecting group. The active ingredient of Fmoc-MMAF-OMe, MMAF (HY-15579), is the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-MMAF-OMe Chemical Structure

CAS No. : 863971-38-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 85	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 85	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

968.23

Formula

C₅₅H₇₇N₅O₁₀

CAS No.

863971-38-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3C4=C(C=CC=C4)C5=C3C=CC=C5)=O)C)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (206.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0328 mL	5.1641 mL	10.3281 mL
5 mM	0.2066 mL	1.0328 mL	2.0656 mL
10 mM	0.1033 mL	0.5164 mL	1.0328 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16(9):2562-70. [Content Brief] [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0328 mL	5.1641 mL	10.3281 mL	25.8203 mL
	5 mM	0.2066 mL	1.0328 mL	2.0656 mL	5.1641 mL
	10 mM	0.1033 mL	0.5164 mL	1.0328 mL	2.5820 mL
	15 mM	0.0689 mL	0.3443 mL	0.6885 mL	1.7214 mL
	20 mM	0.0516 mL	0.2582 mL	0.5164 mL	1.2910 mL
	25 mM	0.0413 mL	0.2066 mL	0.4131 mL	1.0328 mL
	30 mM	0.0344 mL	0.1721 mL	0.3443 mL	0.8607 mL
	40 mM	0.0258 mL	0.1291 mL	0.2582 mL	0.6455 mL
	50 mM	0.0207 mL	0.1033 mL	0.2066 mL	0.5164 mL
	60 mM	0.0172 mL	0.0861 mL	0.1721 mL	0.4303 mL
	80 mM	0.0129 mL	0.0646 mL	0.1291 mL	0.3228 mL
	100 mM	0.0103 mL	0.0516 mL	0.1033 mL	0.2582 mL

Fmoc-MMAF-OMe Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-MMAF-OMe863971-38-4Microtubule/TubulinADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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