2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Microtubule/Tubulin ADC Cytotoxin
  4. Fmoc-MMAF-OMe

Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor with an Fmoc protecting group. The active ingredient of Fmoc-MMAF-OMe, MMAF (HY-15579), is the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-MMAF-OMe Chemical Structure

Fmoc-MMAF-OMe Chemical Structure

CAS No. : 863971-38-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 85 In-stock
Solution
10 mM * 1 mL in DMSO USD 85 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 80 In-stock
25 mg USD 120 In-stock
50 mg USD 180 In-stock
100 mg USD 240 In-stock
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500 mg   Get quote  

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Fmoc-MMAF-OMe Related Antibodies

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Description

Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor with an Fmoc protecting group. The active ingredient of Fmoc-MMAF-OMe, MMAF (HY-15579), is the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs)[1].

Molecular Weight

968.23

Formula

C55H77N5O10
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3C4=C(C=CC=C4)C5=C3C=CC=C5)=O)C)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (206.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0328 mL 5.1641 mL 10.3281 mL
5 mM 0.2066 mL 1.0328 mL 2.0656 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0328 mL 5.1641 mL 10.3281 mL 25.8203 mL
5 mM 0.2066 mL 1.0328 mL 2.0656 mL 5.1641 mL
10 mM 0.1033 mL 0.5164 mL 1.0328 mL 2.5820 mL
15 mM 0.0689 mL 0.3443 mL 0.6885 mL 1.7214 mL
20 mM 0.0516 mL 0.2582 mL 0.5164 mL 1.2910 mL
25 mM 0.0413 mL 0.2066 mL 0.4131 mL 1.0328 mL
30 mM 0.0344 mL 0.1721 mL 0.3443 mL 0.8607 mL
40 mM 0.0258 mL 0.1291 mL 0.2582 mL 0.6455 mL
50 mM 0.0207 mL 0.1033 mL 0.2066 mL 0.5164 mL
60 mM 0.0172 mL 0.0861 mL 0.1721 mL 0.4303 mL
80 mM 0.0129 mL 0.0646 mL 0.1291 mL 0.3228 mL
100 mM 0.0103 mL 0.0516 mL 0.1033 mL 0.2582 mL
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Fmoc-MMAF-OMe Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-MMAF-OMe863971-38-4Microtubule/TubulinADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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