Opioid Receptor Agonist

Opioid Receptor Agonists (153):

Cat. No.	Product Name	Effect	Purity

HY-10886

MCOPPB	Agonist
MCOPPB is an orally active and selective agonist of Nociceptin/Orphanin FQ–Receptor. MCOPPB inhibits signaling through the NOP receptor in the mouse brain. MCOPPB is used in anxiety disorders research.

HY-136623

BW443C	Agonist
BW443C is a selective opioid receptor agonist. BW443C has antinociceptive effect.

HY-135238

(rel)-RSD 921	Agonist
(rel)-RSD 921 (PD-117302) is a κ-opioid receptor agonist. (rel)-RSD 921 did not have a greater food-inducing effect in obese than in lean Zucker rats; in both obese and lean Zucker rats, lean rats were more sensitive to its initial food-inducing effect but ultimately ate less.

HY-14157A

ADL-5747 hydrochloride	Agonist
ADL-5747 hydrochloride is a selective and orally active agonist of the δ-opioid receptor (DOR). By binding to the δ-opioid receptors, ADL-5747 hydrochloride activates these receptors, thereby playing a role in pain management pathways. ADL-5747 hydrochloride can be used for research into pain management mechanisms.

HY-106756

Spiradoline	Agonist
Spiradoline (U-62066), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a K_i of 8.6 nM in guinea pig. The K_i values of Spiradoline for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier.

HY-130696

(+)-U-50488	Agonist
(+)-U-50488 ((+)-Trans-(1R,2R)-U-50488) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997).

HY-15997A

(+)-U-50488 hydrochloride	Agonist
(+)-U-50488 (hydrochloride) (+)-Trans-(1R,2R)-U-50488 hydrochloride) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997).

HY-P1866

β-Endorphin, equine	Agonist
β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. Analgesic properties.

HY-134189

EST73502	Agonist
EST73502 is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with K_is of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 has antinociceptive activity.

HY-P3870B

DALDA TFA	Agonist
DALDA TFA is a potent and highly selective μ-opioid receptor agonist with a K_i of 1.69 nM. DALDA TFA shows antinociceptive and respiratory effects.

HY-101202A

(Rac)-SNC80	Agonist
(Rac)-SNC80 is a racemate of SNC80 (HY-101202). SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a K_i of 1.78 nM and an IC₅₀ of 2.73 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.

HY-105525A

Sameridine hydrochloride	Agonist
Sameridine hydrochloride is a local anesthetic and local analgesic.

HY-162728

RO-76	Agonist
RO-76 is a mu opioid receptor (μOR) selective partial agonist. RO-76 binds to μOR-G-protein complex with an EC₅₀ value of 454 nM. RO-76 reduces β-Arrestin-1/2 recruitment. RO-76 shows antinociception activity.

HY-P3517

β-Endorphin (6-31), human	Agonist
β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation.

HY-B0380S1

Trimebutine-d₅ fumarate	Agonist
Trimebutine-d₅ (fumarate) is deuterium labeled Trimebutine.

HY-P3550

β-Lipotropin (60-65)	Agonist
β-Lipotropin (60-65) (β-LPH (60-65)), an opioid peptide, is a potent opioid agonist.

HY-P0179A

β-Casomorphin, bovine TFA	Agonist
β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a opioid peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay.

HY-P1481

β-Casomorphin, human	Agonist
is an opioid peptide, acts as an agonist of opioid receptor.

HY-P3647A

[DPro10] Dynorphin A (1-11), porcine hydrochloride	Agonist
[DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a K_i value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property.

HY-153471

MOR agonist-1	Agonist
MOR agonist-1 is a MOR (μ-opioid receptor) agonist. MOR agonist-1 has good analgesic effect. MOR agonist-1 can be used for the research of pain and pain-related disorders.

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