2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. PAK

PAK

p21 activated kinases

PAK

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PAKs (p21-activated kinases) are a family of six serine/threonine kinases that act as key effectors of RHO family GTPases in mammalian cells. PAKs are subdivided into two groups: group I (PAK1, PAK2, and PAK3) and group II (PAK4, PAK5, and PAK6), based on their domain architecture and regulation. Group I PAKs are activated by GTPases such as Cdc42, Rac, TC10, CHP, and Wrch-1, as well as in a GTPase-independent manner. Group II PAKs are generally not activated by Cdc42/Rac binding. PAK plays important roles in cytoskeletal organization, cellular morphogenesis, and survival, and members of this family have been implicated in many diseases including cancer, infectious diseases, and neurological disorders.

PAKs participate in various signaling networks. PAKs activate the MAPK pathway by phosphorylating Raf1 in addition to NF-κB. PAKs also phosphorylate a number of regulators of the cytoskeleton such as MLCK, LIMK, filamin A, ILK, merlin, and Arpc1b. In addition, PAKs regulate survival and apoptotic pathways through phosphorylation of its effectors such as DLC1 and BimL. On translocation to the nucleus, PAKs directly affect gene transcription. Several transcription factors and transcriptional co-regulators such as FKHR, SHARP, CTBP1 and SNAI1 are substrates to PAK1. PAKs also regulate cell cycle progression through phosphorylation of histone H3, Aurora A and PlK1.

PAK Isoform Specific Products:

PAK Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-143490
    PAK4-IN-2
    		Inhibitor 99.78%
    PAK4-IN-2 is a highly potent PAK4 inhibitor with IC50 value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer.
    PAK4-IN-2
  • HY-P2624A
    st-Ht31 ammonium
    		Inhibitor
    st-Ht31 ammonium is a membrane-permeable peptide inhibitor of?protein kinase A (PKA) anchoring. st-Ht31 ammonium induces robust cholesterol/phospholipid efflux. st-Ht31 ammonium completely reverses foam cell formation and restores the metabolic health of macrophage.
    st-Ht31 ammonium
  • HY-15324
    PRT062607 acetate
    		Inhibitor 99.83%
    PRT062607 (P505-15) acetate is an orally available Syk inhibitor (IC50: 1 nM) that inhibits inflammation and induction Apoptosis. PRT062607 acetate exerts potent antitumor activity in tumor xenograft mouse models..
    PRT062607 acetate
  • HY-N8303
    Gardenin A
    		Inhibitor
    Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects.
    Gardenin A
  • HY-131043
    NVS-PAK1-C
    		Inhibitor 99.2%
    NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM).
    NVS-PAK1-C
  • HY-15027S1
    5-Aminosalicylic acid-d3
    		99.38%
    5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].
    5-Aminosalicylic acid-d<sub>3</sub>
  • HY-120940A
    AZ13705339 hemihydrate
    		Inhibitor 99.77%
    AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers.
    AZ13705339 hemihydrate
  • HY-116269
    AZA197
    		Inhibitor 98.28%
    AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts.
    AZA197
  • HY-11063R
    Fingolimod (Standard)
    		Activator
    Fingolimod (Standard) is the analytical standard of Fingolimod. This product is intended for research and analytical applications. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant.
    Fingolimod (Standard)
  • HY-11063S1
    Fingolimod-d4 hydrochloride
    		Activator ≥99.0%
    Fingolimod-d4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].
    Fingolimod-d<sub>4</sub> hydrochloride
  • HY-RS09992
    Pak3 Rat Pre-designed siRNA Set A
    		Inhibitor

    Pak3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pak3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Pak3 Rat Pre-designed siRNA Set A
    Pak3 Rat Pre-designed siRNA Set A
  • HY-146681
    PAK1-IN-1
    		Inhibitor
    PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner.
    PAK1-IN-1
  • HY-RS09997
    Pak5 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Pak5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pak5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Pak5 Mouse Pre-designed siRNA Set A
    Pak5 Mouse Pre-designed siRNA Set A
  • HY-RS09989
    PAK2 Rat Pre-designed siRNA Set A
    		Inhibitor

    PAK2 Rat Pre-designed siRNA Set A contains three designed siRNAs for PAK2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PAK2 Rat Pre-designed siRNA Set A
    PAK2 Rat Pre-designed siRNA Set A
  • HY-155179
    ZMF-23
    		Inhibitor
    ZMF-23 is a PAK1/HDAC6 dual inhibitor. ZMF-23 inhibits PAK1 and HDAC6 regulated aerobic glycolysis and migration. ZMF-23 induces TNF-α-regulated necroptosis, and further enhances apoptosis. ZMF-23 inhibits the Warburg effect and cell migration. ZMF-23 can be used for research of triple-negative breast cancer (TNBC).
    ZMF-23
  • HY-11063S
    Fingolimod-d4
    		Activator 98.97%
    Fingolimod-d4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].
    Fingolimod-d<sub>4</sub>
  • HY-RS09998
    Pak5 Rat Pre-designed siRNA Set A
    		Inhibitor

    Pak5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pak5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Pak5 Rat Pre-designed siRNA Set A
    Pak5 Rat Pre-designed siRNA Set A
  • HY-RS10000
    Pak6 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Pak6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pak6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Pak6 Mouse Pre-designed siRNA Set A
    Pak6 Mouse Pre-designed siRNA Set A
  • HY-15027S2
    5-Aminosalicylic acid-13C6
    5-Aminosalicylic acid-13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].
    5-Aminosalicylic acid-<sup>13</sup>C<sub>6</sub>
  • HY-RS09983
    PAK1 Human Pre-designed siRNA Set A
    		Inhibitor

    PAK1 Human Pre-designed siRNA Set A contains three designed siRNAs for PAK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PAK1 Human Pre-designed siRNA Set A
    PAK1 Human Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
PAK Isoform Comparison

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