2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. PI4K

PI4K

Phosphatidylinositol 4 kinases; PI4 kinases

PI4K

Related Products

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Phosphatidylinositol 4-kinases (PI4Ks) catalyze the synthesis of phosphatidylinositol 4-phosphate (PI4P), an important intermediate for the synthesis of membrane polyphosphoinositides, regulators of multiple cellular functions. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi. Based on enzymatic differences, two classes of PI4K have been distinguished termed Types II (PI4KII) and III (PI4KIII), and each of which contains α and β isoforms.

PI4KII alpha and beta have similar biochemical properties. PI4KIIIs (α- and β-forms) are soluble enzymes structurally related to PI3-kinases, and sensitive to PI3-kinase inhibitors, such as Wortmannin. PI4KIIs produce PtdIns 4-phosphate, an early key signaling molecule in phosphatidylinositol cycle, which is indispensable for T cell activation. PI4KIIIs plays a key role in the production of replication complexes (viral factories) of a number of positive-sense RNA viruses and represents a potential target for novel pan-viral therapeutics.

PI4K Isoform Specific Products:

PI4K Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112435
    UCT943
    		Inhibitor 99.08%
    UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor. UCT943 inhibits the P. vivax PI4K (PvPI4K) enzyme with an IC50 of 23 nM.
    UCT943
  • HY-150598
    CHMFL-PI4K-127
    		Inhibitor 99.94%
    CHMFL-PI4K-127 (compound 15g) is an orally active, potent and high selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor, with an IC50 of 0.9 nM. CHMFL-PI4K-127 exhibits potent activity against 3D7 Plasmodium falciparum, with an EC50 of 25.1 nM. CHMFL-PI4K-127 shows antimalaria efficacy.
    CHMFL-PI4K-127
  • HY-118525
    AL-9
    		Inhibitor 99.68%
    AL-9 is a inhibitor of PI4KIIIα, with the IC50 of 0.57 μM, that can inhibit HCV replication.
    AL-9
  • HY-161357
    KR-27370
    		Inhibitor
    KR-27370 (compound 7f) is an antiviral agent and selective PI4KIIIβ/PI4KIIIα inhibitor (IC50: 3.1 nM/15.8 nM), against hRV, Ke Saatchivirus and other enteroviruses have inhibitory activity[1].br/.
    KR-27370
  • HY-148075
    PI4KIIIbeta-IN-11
    		Inhibitor
    PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum.
    PI4KIIIbeta-IN-11
  • HY-RS10468
    Pi4ka Rat Pre-designed siRNA Set A
    		Inhibitor

    Pi4ka Rat Pre-designed siRNA Set A contains three designed siRNAs for Pi4ka gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Pi4ka Rat Pre-designed siRNA Set A
    Pi4ka Rat Pre-designed siRNA Set A
  • HY-RS10469
    PI4KB Human Pre-designed siRNA Set A
    		Inhibitor

    PI4KB Human Pre-designed siRNA Set A contains three designed siRNAs for PI4KB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PI4KB Human Pre-designed siRNA Set A
    PI4KB Human Pre-designed siRNA Set A
  • HY-RS10470
    Pi4kb Mouse Pre-designed siRNA Set A
    		Inhibitor

    Pi4kb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pi4kb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Pi4kb Mouse Pre-designed siRNA Set A
    Pi4kb Mouse Pre-designed siRNA Set A
  • HY-RS10467
    Pi4ka Mouse Pre-designed siRNA Set A
    		Inhibitor

    Pi4ka Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pi4ka gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Pi4ka Mouse Pre-designed siRNA Set A
    Pi4ka Mouse Pre-designed siRNA Set A
  • HY-163765
    Antimalarial agent 41
    		Inhibitor
    Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models.
    Antimalarial agent 41
  • HY-RS10471
    Pi4kb Rat Pre-designed siRNA Set A
    		Inhibitor

    Pi4kb Rat Pre-designed siRNA Set A contains three designed siRNAs for Pi4kb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Pi4kb Rat Pre-designed siRNA Set A
    Pi4kb Rat Pre-designed siRNA Set A
  • HY-RS10466
    PI4KA Human Pre-designed siRNA Set A
    		Inhibitor

    PI4KA Human Pre-designed siRNA Set A contains three designed siRNAs for PI4KA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PI4KA Human Pre-designed siRNA Set A
    PI4KA Human Pre-designed siRNA Set A
  • HY-100603A
    (S)-GSK-F1
    		Inhibitor
    (S)-GSK-F1 (Compound 28) is an inhibitor for type III phosphatidylinositol 4-kinase α (PI4KIIIα). (S)-GSK-F1 inhibits PI4Kα, PI4Kβ, PI4Kγ, PI3Kα, PI3Kβ and PI3Kδ with pIC50 of 8.3, 6.0, 5.6, 5.6, 5.1 and 5.6, respectively. (S)-GSK-F1 exhibits anti-hepatitis C virus (HCV) activity through inhibition of HCV replication. (S)-GSK-F1 exhibits moderate pharmacokinetic characters in rat model.
    (S)-GSK-F1
PI4K Isoform Comparison

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