DP

DP Related Products (40):

By Type:	Pan (10) Selective (18)
By Effects:	Inhibitors (9) Agonists (9) Antagonists (19) Activators (3)

Cat. No.	Product Name	Effect	Purity

HY-109163

Treprostinil palmitil	Agonist	99.62%
Treprostinil palmitil (TP) is the proagent of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC₅₀ values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure proagent and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors.

HY-109186

Pexopiprant	Antagonist	99.40%
Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),K_i ＜ 100nM. Pexopiprant can be used in studies of asthma.

HY-139972

PROTAC(H-PGDS)-7	Inhibitor	99.42%
PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC₅₀ of 17.3 pM.

HY-50848

BW A868C	Antagonist	99.00%
BW A868C, a hydantoin compound, is a BW245C structural analogue. BW A868C is a selective and potent competitive prostaglandin D2 (PGD2) antagonist. BW A868C has no effect on other prostaglandin receptors (IP, EP1, EP2, TP and FP).

HY-19499

AMG-009	Antagonist	98.08%
AMG-009 is a potent antagonist of prostaglandin D2, with IC₅₀ of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.

HY-109134

Pizuglanstat	Inhibitor	99.70%
Pizuglanstat (compound 3) is a prostaglandin D synthase inhibitor with an IC₅₀ of 76 nM for human hematopoietic prostaglandin D synthases (H-PGDS). Pizuglanstat can be used for myodegenerative disease research, such as muscular dystrophy.

HY-16344

Nedocromil sodium	Inhibitor
Nedocromil sodium suppresses the action or formation of multiple mediators, including histamine, leukotriene C₄ (LTC₄), and prostaglandin D₂ (PGD₂).

HY-B0813

Treprostinil diethanolamine	Agonist	99.44%
Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with K_i values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries.

HY-111271A

L 888607 Racemate	Antagonist	99.81%
L 888607 Racemate is a selective prostaglandin D₂ receptor subtype 1 (DP1) antagonist, with K_is of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.

HY-101988S1

Prostaglandin D2-d₉	Activator	≥99.0%
Prostaglandin D2-d₉ is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

HY-13706A

CAY10471	Antagonist
CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. CAY10471 attenuates the progression of tubulointerstitial fibrosis and chronic contact hypersensitivity (CHS) in animal model.

HY-B0195A

Tranilast sodium	Inhibitor
Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC₅₀= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells.

HY-50175A

Laropiprant sodium	Antagonist
Laropiprant sodium is a potent and selective DP receptor antagonist with K_i values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.

HY-112604

MK-8318	Antagonist
MK-8318 is a potent and selective CRTh2 receptor antagonist with a K_i of 5.0 nM.

HY-122147

L-644698	Agonist
L-644698 is a potent and selective human recombinant prostaglandin D2 (PGD2) receptor (hDP) agonist with K_i values of 0.9, 267, 3730, 9280 nM for hDP, hEP2, hEP3, hEP4, respectively. L-644698 induces cyclic AMP production with an EC₅₀ value of 0.5 nM.

HY-100441S1

Treprostinil-¹³C₂,d	Inhibitor
Treprostinil-¹³C₂,d is the ¹³C- and deuterium labeled Treprostinil. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.

HY-14898

AGN 210676	Agonist
AGN 210676 is a selective prostaglandin EP₂ agonist extracted from patent US20070203222A1, Compound example 23, has an EC₅₀ of 5 nM.

HY-101988S

Prostaglandin D2-d₄	Activator
Prostaglandin D2-d₄ is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

HY-118180

CAY10595	Antagonist
CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a K_i of 10 nM.

HY-U00423

CRTH2-IN-1	Antagonist
CRTH2-IN-1 (Ramatroban analog) is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC₅₀ of 6 nM in a human DP2 binding assay.

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