1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Treprostinil diethanolamine

Treprostinil diethanolamine  (Synonyms: UT-15C)

Cat. No.: HY-B0813 Purity: 99.44%
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Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries.

For research use only. We do not sell to patients.

Treprostinil diethanolamine Chemical Structure

Treprostinil diethanolamine Chemical Structure

CAS No. : 830354-48-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Treprostinil diethanolamine:

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1 Publications Citing Use of MCE Treprostinil diethanolamine

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Description

Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries[1][2][3].

IC50 & Target[1]

DP1

4.4 nM (Ki)

EP1

212 nM (Ki)

EP4

826 nM (Ki)

EP3

2505 nM (Ki)

IP

32.1 nM (Ki)

FP

4680 nM (Ki)

EP2

3.6 nM (Ki)

In Vitro

Treprostinil diethanolamine (UT-15C; 0.001-10,000 nM; 60 min; HEK293 cells) has high potency in activating DP1 and EP2 receptors as well as the IP receptor with EC50 values of 0.6 nM, 6.2 nM and 1.9 nM, respectively, 36-fold less active at the EP3 receptor, 95-fold less active at the EP4 and 150-fold less active at the EP1 site than at the IP receptor[1].
Treprostinil diethanolamine (10 μM) increases cAMP accumulation in murine and human hematopoietic stem and progenitor cells (HSPCs) [2].
Treprostinil diethanolamine (10 μM; 2-6 h; PC3 cells) enhances the action of SDF-1 via CXCR4[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Treprostinil diethanolamine (UT-15C; 0.15 mg/kg; i.h.; every 8 h; for 10 d; BALB/c mice) enhances the ability of HSPCs to repopulate the bone marrow and increases bone marrow reconstitution[2].
Treprostinil diethanolamine (0.15 mg/kg; i.h.; every 8 h; for 10 d; BALB/c mice) increases survival of lethally irradiated recipient mice[2].
Treprostinil diethanolamine (0.1 mg/kg; i.h.; for 24h; male lewis rats) inhibits the mRNA expression of TNF-α and IFN-γ and increases in IL-10 expression[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[2]
Dosage: 0.15 mg/kg
Administration: Subcutaneous injection; every 8 hours; for 10 days
Result: Increased survival of lethally irradiated recipient mice.
Animal Model: Male lewis rats[3]
Dosage: 0.1 mg/kg
Administration: Subcutaneous injection; for 24 hours
Result: Decreased the mRNA expression of TNF-α and IFN-γ and increased the expression of IL-10.
Clinical Trial
Molecular Weight

495.65

Formula

C27H45NO7

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=C2C[C@@]3([H])C[C@@H](O)[C@H](CC[C@@H](O)CCCCC)[C@@]3([H])CC2=CC=C1.OCCNCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (252.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0176 mL 10.0878 mL 20.1755 mL
5 mM 0.4035 mL 2.0176 mL 4.0351 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0176 mL 10.0878 mL 20.1755 mL 50.4388 mL
5 mM 0.4035 mL 2.0176 mL 4.0351 mL 10.0878 mL
10 mM 0.2018 mL 1.0088 mL 2.0176 mL 5.0439 mL
15 mM 0.1345 mL 0.6725 mL 1.3450 mL 3.3626 mL
20 mM 0.1009 mL 0.5044 mL 1.0088 mL 2.5219 mL
25 mM 0.0807 mL 0.4035 mL 0.8070 mL 2.0176 mL
30 mM 0.0673 mL 0.3363 mL 0.6725 mL 1.6813 mL
40 mM 0.0504 mL 0.2522 mL 0.5044 mL 1.2610 mL
50 mM 0.0404 mL 0.2018 mL 0.4035 mL 1.0088 mL
60 mM 0.0336 mL 0.1681 mL 0.3363 mL 0.8406 mL
80 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6305 mL
100 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5044 mL
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Treprostinil diethanolamine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Treprostinil diethanolamine
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