Prostaglandin Receptor Agonist

Prostaglandin Receptor Agonists (153):

Cat. No.	Product Name	Effect	Purity

HY-111271

L 888607	Agonist	99.87%
L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a K_i value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite.

HY-106961

ONO 1301	Agonist	99.06%
ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig.

HY-112322

Carbacyclin	Agonist	98.00%
Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.

HY-14839

Evatanepag	Agonist	99.78%
Evatanepag (CP-533536) is a non-prostanoid, potent and selective EP₂ receptor agonist. Evatanepag can induce local bone formation in vivo. Evatanepag can be used in the research of fractures, bone defects, asthma.

HY-107381

(+)-Cloprostenol	Agonist	99.28%
(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.

HY-12956A

Dinoprost tromethamine salt	Agonist	≥98.0%
Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.

HY-N6070

Ricinoleic acid (purity≥85%)	Agonist
Ricinoleic acid (purity≥85%), a hydroxy fatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC₅₀ in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties.

HY-19360

Sulprostone	Agonist	≥99.0%
Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery.

HY-108557

TCS 2510	Agonist	≥99.0%
TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.

HY-19998

Taprenepag isopropyl	Agonist	99.23%
Taprenepag isopropyl is a highly selective EP₂ receptor agonist.

HY-118609

EP4 receptor agonist 2	Agonist	≥99.0%
EP4 receptor agonist 2 (compound 31) a potent EP4 receptor agonist with an EC₅₀ value of 0.8 nM; K_i values of >100000, 38000, 3.1 nM for EP2, EP3, EP4 respectively.

HY-16751

Ralinepag	Agonist	99.79%
Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC₅₀s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.

HY-108415

Cloprostenol sodium salt	Agonist	99.52%
Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist.

HY-139419

Bimatoprost grenod	Agonist	98.34%
Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma.

HY-12184

ONO-AE 248	Agonist	98.27%
ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K(ATP) channels.

HY-109163

Treprostinil palmitil	Agonist	99.62%
Treprostinil palmitil (TP) is the proagent of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC₅₀ values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure proagent and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors.

HY-114910

11-Deoxy Prostaglandin E2	Agonist	≥99.0%
11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC₅₀ of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions.

HY-118189

Misoprostol acid	Agonist	≥99.0%
Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers. Misoprostol is an oral agent used to induce labor.

HY-135259

CAY10580	Agonist
CAY10580 is a potent and selective prostaglandin EP₄ receptor agonist (K_i=35 nM).

HY-112152

GSK726701A	Agonist	98.27%
GSK726701A is a novel prostaglandin E2 receptor 4 (EP4) partial agonist with a pEC₅₀ of 7.4.

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