2. Signaling Pathways
  3. Stem Cell/Wnt
    TGF-beta/Smad
  4. RUNX

RUNX

Runt-related transcription factors; RUNX

Runt-related transcription factors (RUNX) is a transcription factor that regulates the bone development, cell growth and tumor metastasis. There are three RUNX transcription factors in mammals: RUNX1, RUNX2 and RUNX3. RUNX1 is expressed in mesenchymal cells and proliferating chondrocytes, and acts as a compensatory factor for RUNX2 to promote the proliferation and differentiation of osteoblasts; RUNX1 is also expressed in hematopoietic cells and certain cancer cells. RUNX2 is expressed in bones and chondrocytes, and is a key regulator of osteoblast differentiation and chondrocyte hypertrophy. RUNX2 is also highly expressed in the nucleus and cytoplasm of prostate cancer cells, that binds to microtubules in the cytoplasm and is associated with the tumor metastasis. RUNX3 is expressed in hypertrophic chondrocytes plays an anabolic function in cartilage metabolism, and maintains the health of cartilage by regulating the expression of genes such as Acan and Prg4. Runt-related transcription factors dysfunction leads to bone diseases like osteoporosis, skeletal abnormality or osteoarthritis. In addition, runt-related transcription factors is abnormal expressed in certain cancer cells, which is supposed to be associated with tumor development[1][2].

RUNX Isoform Specific Products:

RUNX Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108470
    Ro5-3335
    		Inhibitor 99.52%
    Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation.
    Ro5-3335
  • HY-138617
    AI-10-47
    		Inhibitor 98.93%
    AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM.
    AI-10-47
  • HY-151411
    RUNX1/ETO tetramerization-IN-1
    		Inhibitor 99.88%
    RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor of RUNX1/ETO tetramerization, exhibits anti-leukemic effect. RUNX1/ETO tetramerization-IN-1 specifically targets to NHR2 of RUNX1/ETO (EC50=0.25 μM), restores gene expression down-regulated by RUNX1/ETO. RUNX1/ETO tetramerization-IN-1 inhibits the proliferation of RUNX1/ETO-depending SKNO-1 cells, and reduces the RUNX1/ETO-related tumor growth in a mouse model.
    RUNX1/ETO tetramerization-IN-1
  • HY-107245
    Segetalin B
    		Activator 99.51%
    Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP).
    Segetalin B
RUNX Isoform Comparison

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