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AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM.

For research use only. We do not sell to patients.

AI-10-47 Chemical Structure

AI-10-47 Chemical Structure

CAS No. : 1256094-31-1

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Based on 1 publication(s) in Google Scholar

AI-10-47 Related Antibodies

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Description

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM[1].

In Vitro

AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding[1].
AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AI-10-47 Related Antibodies

Western Blot Analysis[1]

Cell Line: 4 × 106 SEM cells.
Concentration: 10 μM.
Incubation Time: 6 h.
Result: Weakly reduced CBFβ binding to RUNX1 in cells (may due to its poor solubility).
Molecular Weight

279.22

Formula

C13H8F3N3O
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

FC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (358.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5814 mL 17.9070 mL 35.8141 mL
5 mM 0.7163 mL 3.5814 mL 7.1628 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5814 mL 17.9070 mL 35.8141 mL 89.5351 mL
5 mM 0.7163 mL 3.5814 mL 7.1628 mL 17.9070 mL
10 mM 0.3581 mL 1.7907 mL 3.5814 mL 8.9535 mL
15 mM 0.2388 mL 1.1938 mL 2.3876 mL 5.9690 mL
20 mM 0.1791 mL 0.8954 mL 1.7907 mL 4.4768 mL
25 mM 0.1433 mL 0.7163 mL 1.4326 mL 3.5814 mL
30 mM 0.1194 mL 0.5969 mL 1.1938 mL 2.9845 mL
40 mM 0.0895 mL 0.4477 mL 0.8954 mL 2.2384 mL
50 mM 0.0716 mL 0.3581 mL 0.7163 mL 1.7907 mL
60 mM 0.0597 mL 0.2985 mL 0.5969 mL 1.4923 mL
80 mM 0.0448 mL 0.2238 mL 0.4477 mL 1.1192 mL
100 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.8954 mL
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AI-10-47 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AI-10-471256094-31-1OthersCBFβRUNXME-1TURM0-91THP-1U937leukemiacellInhibitorinhibitorinhibit

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