2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Renin

Renin

Renin

Related Products

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Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.

Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.

Renin Related Products (49):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N12763
    Sodium new houttuyfonate
    		Inhibitor
    Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC50 of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1.
    Sodium new houttuyfonate
  • HY-105205
    Terlakiren
    		Inhibitor
    Terlakiren (CP-80,794) is an orally active inhibitor of renin. Terlakiren inhibits the efficacy of human renin with an IC50 value of 0.7 nM. Terlakiren has potential applications in hypertension.
    Terlakiren
  • HY-P2097
    L-363564
    		Inhibitor
    L-363564 is a renin inhibitor. L-363564 can be used in cardiovascular disease related research.
    L-363564
  • HY-12176AS
    Aliskiren-d6 hydrochloride
    		Inhibitor
    Aliskiren-d6 (hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor.
    Aliskiren-d<sub>6</sub> hydrochloride
  • HY-P2130
    SR 42128
    		Inhibitor
    SR 42128 is a potent renin inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited.
    SR 42128
  • HY-P5388
    Renin inhibitor peptide,rat
    		Inhibitor
    Renin inhibitor peptide,rat is a biological active peptide. (A specific rat renin inhibitor.)
    Renin inhibitor peptide,rat
  • HY-106113
    Ditekiren
    		Inhibitor
    Ditekiren (U 71038) is a pseudohexapeptide renin inhibitor. Renin is an enzyme that plays a crucial role in regulating blood pressure and fluid balance. By inhibiting the activity of renin, ditekiren slows down the formation of angiotensin II, a potent vasoconstrictor that can raise blood pressure. Ditekiren can be used for research in the field of blood pressure reduction.
    Ditekiren
  • HY-12177S
    Aliskiren-d6 hemifumarate
    		Inhibitor
    Aliskiren-d6 (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM[1][2].
    Aliskiren-d<sub>6</sub> hemifumarate
  • HY-129695
    PD 132002
    		Inhibitor
    PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure.
    PD 132002
  • HY-129412
    A-74273
    		Inhibitor
    A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension.
    A-74273
  • HY-150963
    Renin inhibitor-1
    		Inhibitor
    Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases.
    Renin inhibitor-1
  • HY-P1572
    Handle region peptide, rat
    		Antagonist
    Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
    Handle region peptide, rat
  • HY-120455
    PD 125967
    		Inhibitor
    PD 125967 is an oligopeptide renin inhibitor. PD 125967 can be used to low blood pressure.
    PD 125967
  • HY-A0184
    Remikiren
    		Inhibitor
    Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension.
    Remikiren
  • HY-N2115R
    Araloside A (Standard)
    		Inhibitor
    Araloside A (Standard) is the analytical standard of Araloside A. This product is intended for research and analytical applications. Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM.
    Araloside A (Standard)
  • HY-P5976
    Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC
    Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate
    Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC
  • HY-12176R
    Aliskiren (Standard)
    		Inhibitor
    Aliskiren (Standard) is the analytical standard of Aliskiren. This product is intended for research and analytical applications. Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia.
    Aliskiren (Standard)
  • HY-105259
    SR 43845
    		Inhibitor
    SR 43845 is a renin inhibitor. SR 43845 decreases blood pressure and inhibits plasma renin activity. SR 43845 can be used for hypertension research.
    SR 43845
  • HY-19145
    PD-134672
    		Inhibitor
    PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.
    PD-134672
  • HY-P2060
    CGP 44099
    		Inhibitor
    CGP 44099 is a renin inhibitor. CGP 44099 can be used to study the ischemic injury and reperfusion arrhythmias in rat hearts.
    CGP 44099