2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Renin

Renin

Renin

Related Products

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Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.

Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.

Renin Related Products (55):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2147
    Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-Ome
    		Inhibitor
    Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-Ome is a specific renin inhibitor.
    Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-Ome
  • HY-P2024
    CP-85339
    		Inhibitor
    CP-85339 is a tetrapeptide renin inhibitor.
    CP-85339
  • HY-B1562B
    Bopindolol (malonate)
    		Inhibitor
    Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.
    Bopindolol (malonate)
  • HY-118033
    SQ 30774
    		Inhibitor
    SQ 30774 is a renin (renin) inhibitor. SQ 30774 has potent in vitro inhibitory effects in primates but not in rats, pigs, or dogs. And imidazolinol renin inhibitors also inhibit PRA and reduce arterial blood pressure in vivo.
    SQ 30774
  • HY-N12763
    Sodium new houttuyfonate
    		Inhibitor
    Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC50 of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1.
    Sodium new houttuyfonate
  • HY-105205
    Terlakiren
    		Inhibitor
    Terlakiren (CP-80,794) is an orally active inhibitor of renin. Terlakiren inhibits the efficacy of human renin with an IC50 value of 0.7 nM. Terlakiren has potential applications in hypertension.
    Terlakiren
  • HY-P2097
    L-363564
    		Inhibitor
    L-363564 is a renin inhibitor. L-363564 can be used in cardiovascular disease related research.
    L-363564
  • HY-B0224A
    Chlorothiazide sodium
    		Inhibitor
    Chlorothiazide sodium is an orally active diuretic and anti-hypertensive agent.
    Chlorothiazide sodium
  • HY-12176AS
    Aliskiren-d6 hydrochloride
    		Inhibitor
    Aliskiren-d6 (hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor.
    Aliskiren-d<sub>6</sub> hydrochloride
  • HY-P2130
    SR 42128
    		Inhibitor
    SR 42128 is a potent renin inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited.
    SR 42128
  • HY-P5388
    Renin inhibitor peptide,rat
    		Inhibitor
    Renin inhibitor peptide,rat is a biological active peptide. (A specific rat renin inhibitor.)
    Renin inhibitor peptide,rat
  • HY-106113
    Ditekiren
    		Inhibitor
    Ditekiren (U 71038) is a pseudohexapeptide renin inhibitor. Renin is an enzyme that plays a crucial role in regulating blood pressure and fluid balance. By inhibiting the activity of renin, ditekiren slows down the formation of angiotensin II, a potent vasoconstrictor that can raise blood pressure. Ditekiren can be used for research in the field of blood pressure reduction.
    Ditekiren
  • HY-123415
    PD 134922
    		Inhibitor
    PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC50 of 15 nM against HIV-1 protease.
    PD 134922
  • HY-12172
    MK-8141
    		Inhibitor
    MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.
    MK-8141
  • HY-12177S
    Aliskiren-d6 hemifumarate
    		Inhibitor
    Aliskiren-d6 (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM[1][2].
    Aliskiren-d<sub>6</sub> hemifumarate
  • HY-129695
    PD 132002
    		Inhibitor
    PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure.
    PD 132002
  • HY-B0224R
    Chlorothiazide (Standard)
    		Modulator 99.32%
    Chlorothiazide (Standard) is the analytical standard of Chlorothiazide. This product is intended for research and analytical applications. Chlorothiazide is an orally active diuretic and anti-hypertensive agent.
    Chlorothiazide (Standard)
  • HY-129412
    A-74273
    		Inhibitor
    A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension.
    A-74273
  • HY-150963
    Renin inhibitor-1
    		Inhibitor
    Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases.
    Renin inhibitor-1
  • HY-P1572
    Handle region peptide, rat
    		Antagonist
    Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
    Handle region peptide, rat