Renin inhibitor-1

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Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC₅₀s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases.

For research use only. We do not sell to patients.

Renin inhibitor-1 Chemical Structure

CAS No. : 1093082-54-2

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Description	Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC₅₀s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases^[1].
IC₅₀ & Target	IC₅₀: 0.9 nM (rh-renin); 1.8 nM (hPRA)^[1]
In Vivo	Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	414.50
Formula	C₂₂H₃₀N₄O₄
CAS No.	1093082-54-2
SMILES	O=C(OC)NCCCN1C=C(CN(C2CC2)C([C@H]3CNCCO3)=O)C4=C1C=CC=C4
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Daisuke Iijima, et al. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. ACS Med. Chem. Lett. 2022, 13, 8, 1351–1357.