2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin
  5. Sirtuin Isoform

Sirtuin

 

Sirtuin Related Products (100):

Cat. No. Product Name Effect Purity
  • HY-123194
    SIRT2/6-IN-1
    		Inhibitor 99.79%
    SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells.
  • HY-16561S
    Resveratrol-d4
    		Activator 99.36%
    Resveratrol-d4 is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].
  • HY-RS12937
    SIRT1 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-15452B
    (R)-Selisistat
    		98.37%
    (R)-Selisistat ((R)-EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
  • HY-NP019
    Agkistrodon halys batroxobin
    		Inhibitor
    Agkistrodon halys batroxobin is a thrombin-like serine protease. Agkistrodon halys batroxobin reduces the expression of Sirt1 and extracellular signal-regulated kinase activation in brain tissue. Agkistrodon halys batroxobin reduces cleaved caspase-3 expression and inhibits neuronal apoptosis in rat.
  • HY-W025074
    BML-278
    		Activator 98.49%
    BML-278 is a SIRT1 activator (EC150: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts.
  • HY-B0150S2
    Nicotinamide-13C6
    		Inhibitor 99.8%
    Nicotinamide-13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
  • HY-RS12943
    SIRT3 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT3 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-N0182A
    Fisetin quarterhydrate
    		Activator 98.64%
    Fisetin quarterhydrate is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
  • HY-N2740
    Agalloside
    		≥98.0%
    Agalloside is a neural stem cell differentiation activator that can be found in Aquilaria agallocha.
  • HY-155725
    Z26395438
    		Inhibitor 99.59%
    Z26395438 (compound 1) is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM.
  • HY-Q49697
    Sirtuin modulator 3
    		Modulator 99.32%
    Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative, acts as a sirtuin modulator.
  • HY-RS12948
    Sirt5 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sirt5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-130479
    AdipoR agonist 1
    		Activator ≥98.0%
    AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research.
  • HY-B0130AR
    Perindopril (erbumine) (Standard)
    Perindopril (erbumine) (Standard) is the analytical standard of Perindopril (erbumine). This product is intended for research and analytical applications. Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.
  • HY-RS12950
    SIRT6 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT6 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-155728
    Sirt1/2-IN-3
    		Inhibitor
    Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC50s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines.
  • HY-155727
    Sirt1/2-IN-2
    		Inhibitor
    Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines.
  • HY-136479
    F0911-7667
    		Agonist
    F0911-7667 is a SIRT1 activator that induces autophagic cell death in U87MG and T98G cells by activating the AMPK-mTOR-ULK complex. CWR tripeptide was also identified as a SIRT1 activator that reduced p53 acetylation in IMR32 neuroblastoma cells and protected cells from cell death induced by Aβ fragments.
  • HY-152090
    Antiproliferative agent-17
    		Inhibitor
    Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity.