Sirtuin Inhibitor

Sirtuin Inhibitors (44):

Cat. No.	Product Name	Effect	Purity

HY-15452

Selisistat	Inhibitor	99.87%
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC₅₀ of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease.

HY-112587

MC3482	Inhibitor	99.22%
MC3482 is a specific sirtuin5 (SIRT5) inhibitor.

HY-B0150S

Nicotinamide-d₄	Inhibitor	99.71%
Nicotinamide-d₄ is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-13423

Tenovin-1	Inhibitor	99.88%
Tenovin-1, a p53 activator, protects p53 from MDM2-mediated degradation. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor.

HY-158426

2-APQC	Inhibitor	99.70%
2-APQC is a SIRT3 activator with the K_d value of 2.756 μM. 2-APQC improves heart failure in vitro and in vivo.

HY-112634

SIRT5 inhibitor 1	Inhibitor	99.65%
SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC₅₀ of 0.11 μM.

HY-103721

SIRT6-IN-2	Inhibitor	99.85%
SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC₅₀: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects.

HY-133998

SIRT-IN-3	Inhibitor	99.12%
SIRT-IN-3 is a potent SIRT inhibitor, with an IC₅₀ of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC₅₀ of 74 μM and 235 μM for SIRT2 and SIRT3, respectively).

HY-124113

4'-Bromo-resveratrol	Inhibitor	99.79%
4'-Bromo-resveratrol is a potent and dual inhibitor Sirtuin-1 and Sirtuin-3. 4'-Bromo-resveratrol inhibits melanoma cell growth through mitochondrial metabolic reprogramming. 4'-Bromo-resveratrol imparts antiproliferative effects in melanoma cells through a metabolic reprogramming and affecting the cell cycle and apoptosis signaling.

HY-108986

JFD00244	Inhibitor	98.03%
JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against SARS-CoV-2.

HY-123194

SIRT2/6-IN-1	Inhibitor	98.44%
SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC₅₀s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells.

HY-163316

SIRT4-IN-1	Inhibitor
SIRT4-IN-1 (compound 69) is selective sirtuin 4 (Sirt4) inhibitor with an IC₅₀ of 16 μM.SIRT4-IN-1 shows no relevant effects on other sirtuin isoforms.

HY-RS12948

Sirt5 Mouse Pre-designed siRNA Set A	Inhibitor
Sirt5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-B0150S2

Nicotinamide-¹³C₆	Inhibitor	99.8%
Nicotinamide-¹³C₆ is the ¹³C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-155725

Z26395438	Inhibitor	99.59%
Z26395438 (compound 1) is a potent Sirtuin-1 inhibitor, with an IC₅₀ value of 1.6 μM.

HY-155728

Sirt1/2-IN-3	Inhibitor
Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines.

HY-155727

Sirt1/2-IN-2	Inhibitor
Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines.

HY-152090

Antiproliferative agent-17	Inhibitor
Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity.

HY-151522

SIRT2-IN-10	Inhibitor
SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC₅₀ of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease.

HY-112428

Sirt2-IN-2	Inhibitor
Sirt2-IN-2 (Compound 10) is a selective Sirt2 inhibitor with an IC₅₀ of 0.118 μM.

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