VD/VDR

Vitamin D; Vitamin D receptor

VD/VDR

Related Products

Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D₃ [1,25(OH)₂D₃], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D₂ (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D₃ (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D₂ and vitamin D₃.

Topical agents containing active vitamin D₃ (calcitriol, 1α, 25- dihydroxyvitaminD₃, VD₃) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

VD/VDR Related Products (135)
Antibodies (3)

By Effects:	Control (1) Inhibitors (4) Ligand (1) Agonists (16) Antagonists (12) Activators (63) Modulators (6) Chemicals (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-75035

Calcipotriol Impurity C	Activator	99.20%
Calcipotriol Impurity C is the impurity of Calcipotriol, Calcipotriol is a ligand of VDR-like receptors.

HY-13293

Impurity C of Calcitriol	Activator	99.84%
Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-13292

Impurity B of Calcitriol	Activator	98.04%
Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-15266

24R-Calcipotriol	Activator
24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

HY-76585

Paricalcitol-d₆	Activator	99.85%
Paricalcitol-d₆ is the deuterium labeled Paricalcitol. Paricalcitol is a agent used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure[1].

HY-15285

Doxercalciferol-d₃	Activator
Doxercalciferol-d₃3 is the deuterated form of Doxercalciferol, which is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).

HY-130705

Previtamin D3		98.68%
Previtamin D3 is an intermediate in the production of cholecalciferol (vitamin D3).

HY-76937

Impurity of Doxercalciferol	Activator
Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.

HY-15156

1alpha, 24, 25-Trihydroxy VD2	Activator	98.21%
1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog.

HY-131961

Triciferol	Agonist	98.61%
Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC₅₀=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities.

HY-100219

CB1151
CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC₅₀ value of 0.82 nM.

HY-75992

trans-Doxercalciferol		98.20%
trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.

HY-32346

Atocalcitol
Atocalcitol, a vitamin D3 analogue, is used in the study for psoriasis.

HY-75041

Calcitriol Impurities A	Activator	99.78%
Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-77274

Calcitriol Impurities D	Activator
Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-10002R

Calcitriol (Standard)	Agonist
Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-76542S

Vitamin D2-d₆	Activator
Vitamin D2-d₆ is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D[1][2].

HY-15398S

Vitamin D3-d₇	Activator
Vitamin D3-d₇ is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells[1][2].

HY-15264

MC 1046	Activator
MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

HY-15398S3

Vitamin D3-d₃	Activator	98.45%
Vitamin D3-d₃ is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

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VD/VDR

VD/VDR

VD/VDR Related Products (135)

Antibodies (3)

VD/VDR Related Products (135):