2. Signaling Pathways
  3. Anti-infection
  4. Virus Protease

Virus Protease

Virus Protease

Related Products

PDF 0.37 MB

Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156007
    SARS-CoV-2 3CLpro-IN-21
    		Inhibitor
    SARS-CoV-2 3CLpro-IN-21 (Compound D6) irreversibly and covalently inhibits SARS-CoV-2 3CLpro with an IC50 of 0.03 μM. SARS-CoV-2 3CLpro-IN-21 also inhibits SARS-CoV-13CLpro with an IC50 of 0.12μM.
    SARS-CoV-2 3CLpro-IN-21
  • HY-P5312
    Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr
    		Inhibitor
    Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is a WNV NS2B-NS3 protease substrate. Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is used for WNV NS2B-NS3 protease substrate peptide selective inhibitor development.
    Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr
  • HY-B0448S
    Phenytoin-d10
    		Inhibitor ≥98.0%
    Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].
    Phenytoin-d<sub>10</sub>
  • HY-161454
    Antiviral agent 54
    		Inhibitor
    Antiviral agent 54 (compound 33) is a broad-spectrum and orally active antiviral agent. Antiviral agent 54 shows antiviral activity for ZIKV, HCoV-OC43 and influenza A virus (IVA). Antiviral agent 54 decreases the ZIKV RNA and protein level.
    Antiviral agent 54
  • HY-P4209A
    Boc-GRR-AMC TFA
    Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity.
    Boc-GRR-AMC TFA
  • HY-161791
    Mpro ligand 2
    Mpro ligand 2 (Compound 8) is the ligand for target protein, which can be used for synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789).
    Mpro ligand 2
  • HY-151900
    SARS-CoV-2 Mpro-IN-4
    		Inhibitor
    SARS-CoV-2 Mpro-IN-4 is a dual Inhibitor of Main Protease (MPro) and Cathepsin L (CatL), with IC50s of 900 nM and 60 nM respectively. SARS-CoV-2 Mpro-IN-4 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-4 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 value of 8.2 nM.
    SARS-CoV-2 Mpro-IN-4
  • HY-151581
    HCVcc-IN-1
    		Inhibitor
    HCVcc-IN-1 is a benzothiazole-2-thiophene S-glycoside derivative with low toxic and antiviral activity.
    HCVcc-IN-1
  • HY-145842
    Encephalitic alphavirus-IN-1
    		Inhibitor
    Encephalitic alphavirus-IN-1 has antiviral activity for VEEV and EEEV with EC50s of 0.24 μM and 0.16 μM, respectively. Encephalitic alphavirus-IN-1 has robust mouse plasma stability, and no obvious cytotoxicity.
    Encephalitic alphavirus-IN-1
  • HY-W012835S1
    4-Methylanisole-d3
    4-Methylanisole-d3 is the deuterium labeled 4-Methylanisole[1]. 4-Methylanisole (4-Methoxytoluene) is food flavoring agent and can be naturally found in Ylang Ylang fragrance oil[2].
    4-Methylanisole-d<sub>3</sub>
  • HY-168917
    9-AMN
    		Inhibitor
    9-AMN is the inhibitor for SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro), inhibits its deubiquitination (DUB) activity and protease activity with IC50 of 4.55 µM and 4.15 µM. 9-AMN inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC50 of 1.04 µM and 2.35 µM.
    9-AMN
  • HY-161244
    FGA145
    		Inhibitor
    FGA145 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 3.71 μM, 9.82 μM and 53 nM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA145 reveals a multitarget effects in the antiviral activity.
    FGA145
  • HY-B0448AR
    Phenytoin (sodium) (Standard)
    		Inhibitor
    Phenytoin (sodium) (Standard) is the analytical standard of Phenytoin (sodium). This product is intended for research and analytical applications. Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
    Phenytoin (sodium) (Standard)
  • HY-N0470S1
    L-Lysine-13C6,15N2,d9 dihydrochloride
    		Inhibitor
    L-Lysine-13C6,15N2,d9 (dihydrochloride) is the deuterium, 13C-, and 15-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-<sup>13</sup>C<sub>6</sub>,<sup>15</sup>N<sub>2</sub>,d<sub>9</sub> dihydrochloride
  • HY-P10871
    cTEV6-2
    		Inhibitor
    cTEV6-2 binds to the cysteine residue (C151) of tobacco etch virus protease (TEV protease), and covalently inhibits TEV protease with an IC50 of 81.7 nM.
    cTEV6-2
  • HY-B0448S1
    Phenytoin-15N2,13C
    Phenytoin-15N2,13C is the 13C and 15N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].
    Phenytoin-<sup>15</sup>N<sub>2</sub>,<sup>13</sup>C
  • HY-P10858
    UCI-1
    		Inhibitor
    UCI-1 is a SARS-CoV-2 main protease (Mpro) cyclic peptide inhibitor with an IC50 of 160 μM. UCI-1 shows no obvious cytotoxicity at the concentration of inhibiting Mpro. UCI-1 can be used in the study of anti-COVID-19 drugs.
    UCI-1
  • HY-100701
    Dutacatib
    		Inhibitor
    Dutacatib is inhibitor for SARS-CoV-2 3CLpro and cathepsin K, which exhibits antiviral activity and ameliorates the cancer-induced bone diseases.
    Dutacatib
  • HY-156008
    SARS-CoV-2-IN-58
    		Inhibitor
    SARS-CoV-2-IN-58 (Compound 21H) is an antiviral agent against SARS-CoV-2 (EC50: 18 μM). SARS-CoV-2-IN-58 inhibits SARS-CoV-2 Mpro with an IC50 of 0.35 μM.
    SARS-CoV-2-IN-58
  • HY-151251
    CYP2C9/CYP2C19-IN-1
    		Inhibitor
    CYP2C9/CYP2C19-IN-1 (compound 22d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C9/CYP2C19-IN-1 can be used in study of anti-ZIKV.
    CYP2C9/CYP2C19-IN-1
Cat. No. Product Name / Synonyms Application Reactivity