2. Signaling Pathways
  3. Anti-infection
  4. Virus Protease

Virus Protease

Protease

Virus Protease

Related Products

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Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0470R
    L-Lysine (hydrochloride) (Standard)
    		Inhibitor
    L-Lysine hydrochloride (Standard) is the analytical standard of L-Lysine hydrochloride. This product is intended for research and analytical applications. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine (hydrochloride) (Standard)
  • HY-169974
    SARS-CoV-2-IN-107
    		Inhibitor
    SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056)-stimulated RAW264.7 macrophages.
    SARS-CoV-2-IN-107
  • HY-168047
    EBOV-IN-10
    		Inhibitor
    EBOV-IN-10 is an orally active Ebola virus (EBOV) inhibitor with an EC50 value of 0.19 μM.
    EBOV-IN-10
  • HY-162022
    BTA-188
    		Inhibitor
    BTA-188, a pyridazinyl oxime ether, is an orally active, potent inhibitor of rhinoviruses (HRV) and enterovirus (EV) 71 in vitro. BTA-188 inhibits HRV-2 replication with an IC50 of 0.8 nM and an IC90 of 11 nM. BTA-188 inhibits enterovirus with an IC50 of 82 and an IC90 of 109 nM. BTA-188 is a potential chemotherapeutic agent for infections caused by the viruses in the Picornaviridae.
    BTA-188
  • HY-N0184R
    Glycyrrhizic acid (Standard)
    		Inhibitor
    Glycyrrhizic acid (Standard) is the analytical standard of Glycyrrhizic acid. This product is intended for research and analytical applications. Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
    Glycyrrhizic acid (Standard)
  • HY-23120
    1-Hydroxyguanidine sulfate
    1-Hydroxyguanidine sulfate is an antitumor agent that inhibits mast cell P815, leukaemia P388, leukaemia L1210 and carcinosarcoma Walker 256 cells growth. 1-Hydroxyguanidine sulfate also has antiviral activity.
    1-Hydroxyguanidine sulfate
  • HY-159911
    SARS-CoV-2 Mpro-IN-29
    		Inhibitor
    SARS-CoV-2 Mpro-IN-29 (Compound 7) is an inhibitor of the SARS-CoV-2 main protease (Mpro) with an IC50 of 310 nM and an EC50 of 0.5 μM in Vero cells. SARS-CoV-2 Mpro-IN-29 binds to the active site of Mpro, blocking the cleavage of viral polyproteins, showing significant antiviral activity and enhanced metabolic function. SARS-CoV-2 Mpro-IN-29 holds potential for research on SARS-CoV-2 antiviral agents.
    SARS-CoV-2 Mpro-IN-29
  • HY-169815
    HCV NS5B polymerase-IN-2
    		Inhibitor
    HCV NS5B polymerase-IN-2 (Compound 298) is a Ns5b polymerase inhibitor. HCV NS5B polymerase-IN-2 is promising for research of hepatitis C virus (HCV) infections.
    HCV NS5B polymerase-IN-2
  • HY-B0448R
    Phenytoin (Standard)
    		Inhibitor
    Phenytoin (Standard) is the analytical standard of Phenytoin. This product is intended for research and analytical applications. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
    Phenytoin (Standard)
  • HY-159961
    SARS-CoV-2 Mpro-IN-34
    		Inhibitor
    SARS-CoV-2 Mpro-IN-34 (Compound 26) is an inhibitor for SARS-CoV-2 Mpro with an IC50 of 6 nM. SARS-CoV-2 Mpro-IN-34 exhibits inhibitory efficacy against OC43 Mpro with an IC50 of 33 nM. SARS-CoV-2 Mpro-IN-34 exhibits antiviral activity in SARS-CoV-2 infected Vero E6 cell with an EC50 of 0.103 μM.
    SARS-CoV-2 Mpro-IN-34
  • HY-106161S1
    Rupintrivir-d7
    		Inhibitor
    Rupintrivir-d7 is a deuterated labeled Rupintrivir. Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.
    Rupintrivir-d<sub>7</sub>
  • HY-169012
    PSB-21110
    		Inhibitor
    PSB-21110 is an irreversible SARS-CoV-2 Mpro inhibitor with EC50 value of 2.68 nM. PSB-21110 has antiviral activity.
    PSB-21110
  • HY-B1290S3
    2-Phenylethanol-13C2
    		Inhibitor
    2-Phenylethanol-13C2 is 13C labeled β-Caryophyllene (HY-B1290). β-Caryophyllene is a CB2 receptor agonist.
    2-Phenylethanol-<sup>13</sup>C<sub>2</sub>
  • HY-N0731R
    Genkwanin (Standard)
    		Inhibitor
    Genkwanin (Standard) is the analytical standard of Genkwanin. This product is intended for research and analytical applications. Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.
    Genkwanin (Standard)
  • HY-I0660R
    Picolinic acid (Standard)
    		Inhibitor
    Picolinic acid (Standard)
  • HY-120863
    (Rac)-PD 135390
    		Inhibitor
    (Rac)-PD 135390 is a dipeptide and an HIV-1 protease inhibitor with an IC50 of 2 nM. (Rac)-PD 135390 can be utilized in antiviral research.
    (Rac)-PD 135390
  • HY-115805
    YKL-04-085
    		Inhibitor
    YKL-04-085 is potent inhibitors of viral translation, with an IC90 of 0.555 μM for DENV2. YKL-04-085 is devoid of any kinase activity.
    YKL-04-085
  • HY-N0193R
    Artesunate (Standard)
    		Inhibitor 99.84%
    Artesunate (Standard) is the analytical standard of Artesunate. This product is intended for research and analytical applications. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
    Artesunate (Standard)
  • HY-161777
    SARS-CoV-2 Mpro-IN-23
    		Inhibitor
    SARS-CoV-2 Mpro-IN-23 (Compound 2) is an inhibitor for SARS-CoV-2 main protease (Mpro), which inhibits wildtype Mpro and mutant Mpro variants, with IC50 of 0.057-0.92 μM. SARS-CoV-2 Mpro-IN-23 inhibits the post-entry viral processes of wild-type SARS-CoV-2 single-round infectious particles (SRIPs), suppresses the viral replication of Mpro wildtype and Mpro mutants with EC50 of 0.02-0.52 μM.
    SARS-CoV-2 Mpro-IN-23
  • HY-108325S
    Brequinar-d3
    		Inhibitor
    Brequinar-d3 (DUP785-d3) is deuterium labeled Brequinar. Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.
    Brequinar-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity