Wnt

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The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three Wnt signaling pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the protein Dishevelled inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, the noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell, and the noncanonical Wnt/calcium pathway regulates calcium inside the cell. The clinical importance of Wnt signaling pathway has been demonstrated by mutations that lead to a variety of diseases, including breast and prostate cancer, glioblastoma, type II diabetes.

Wnt Related Products (184)
Antibodies (26)

By Effects:	Inhibitors (120) Agonists (10) Degrader (1) Antagonists (7) Activators (23) Modulators (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-19987

BML-284	Activator	99.95%
BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC₅₀ of 700 nM.

HY-103705

iCRT3	Inhibitor	99.55%
iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.

HY-100830

NCB-0846	Inhibitor	99.61%
NCB-0846 is an orally available TNIK inhibitor with an IC₅₀ of 21 nM.

HY-N0889

Ginkgetin	Inhibitor	99.86%
Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC₅₀ of 5.92 μΜ.

HY-P1416A

Foxy-5 TFA	Agonist	99.02%
Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.

HY-15721

FH535	Inhibitor	98.72%
FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.

HY-123071A

Box5 TFA	Antagonist
Box5 TFA is a potent Wnt5a antagonist. Box5 TFA inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca²⁺ release. Box5 TFA inhibits cell migration. Box5 TFA has the potential for the research of melanoma.

HY-32736

Triptonide	Inhibitor	99.89%
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC₅₀ of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.

HY-N1411

Platycodin D		99.93%
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D.

HY-18988

ETC-159	Inhibitor	98.96%
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. ETC-159 inhibits β-catenin reporter activity with an IC₅₀ of 2.9 nM.

HY-N0279

Cardamonin	Inhibitor	98.38%
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities.

HY-101275

EMT inhibitor-1	Inhibitor	99.45%
EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

HY-12879

IWP-4	Inhibitor	99.44%
IWP-4 is a small molecule Wnt inhibitor with an IC₅₀ of 25 nM.

HY-101130

PNU-74654	Inhibitor	99.93%
PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC₅₀ of 129.8 μM in NCI-H295 cell.

HY-16665

iCRT 14	Inhibitor	99.29%
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC₅₀ of 40.3 nM against Wnt responsive STF16 luciferase.

HY-101090

KYA1797K	Inhibitor	≥98.0%
KYA1797K is a potent and selective Wnt/β-catenin inhibitor with an IC₅₀ of 0.75 µM.

HY-13822

SKI II	Inhibitor	99.78%
SKI-II is an oral active and synthetic inhibitor of sphingosine kinase (SK) activity, with IC₅₀ values of 78 μM and 45 μM for SK1 and for SK2, respectively. SKI II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation.

HY-122816

HLY78	Activator	98.49%
HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research.

HY-100711

Prodigiosin	Inhibitor	99.89%
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the Wnt/β-catenin pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.

HY-12681

CCT251545	Inhibitor	99.39%
CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with an IC₅₀ of 5 nM in 7dF3 cells. CCT251545 is a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

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Wnt

Wnt

Wnt Related Products (184)

Antibodies (26)

Wnt Related Products (184):