2. Signaling Pathways
  3. Immunology/Inflammation
  4. FAP

FAP

Fibroblast activation protein

Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147057A
    FAP-2286 acetate
    FAP-2286 acetate is the conjugate of a fibroblast activation protein (FAP)-binding peptide. FAP-2286 acetate can be labeled with radionuclides for diagnostic applications. FAP-2286 acetate has antitumor activity.
    FAP-2286 acetate
  • HY-P3392A
    Zilganersen sodium
    		Inhibitor
    Zilganersen sodium is a glial fibrillary acidic protein (GFAP) inhibitor. Zilganersen sodium can be used in Alexander disease (AxD) research.
    Zilganersen sodium
  • HY-164316A
    FT-FAPI-12_9 TFA
    		99.48%
    FT-FAPI-12_9 (TFA) is an FAP ligand that can be used for the synthesis of the FAP-targeted radiotracer FAPI-46 (HY-137331).
    FT-FAPI-12_9 TFA
  • HY-158326
    FAP-IN-4
    		Inhibitor
    FAP-IN-4 (Comp 10) is a fibroblast activation protein (FAP) inhibitor and a 18F-labeled PET tracer targeting FAP. FAP-IN-4 can be used for cancer research.
    FAP-IN-4
  • HY-D2281
    [99mTc]Tc-6–1
    [99m Tc]Tc-6-1, a 99mTc-labeled FAPI-46 derivative, is a specific fibroblast activation protein (FAP)-targeted radiotracer. [99m Tc]Tc-6-1 exhibits good tumor uptake and acts as a promising molecular tracer for FAP tumor imaging.
    [99mTc]Tc-6–1
  • HY-161074
    PNT6555
    PNT6555 is a fibroblast activation protein-α (FAP) inhibitor. PNT6555 has antitumor activity. PNT6555 can be used for imaging of FAP-positive tumors.
    PNT6555
  • HY-128642A
    FAPI-2 TFA
    		98.05%
    FAPI-2 TFA is a type of small molecule fibroblast activation protein inhibitor (FAPI) that targets the fibroblast activation protein (FAP) and has an inhibitory effect. This specific targeting ability makes FAPI-2 TFA an effective tumor imaging agent, which can be used in cancer research. FAPI-2 TFA can be used to synthesize 68Ga-FAPI-2 (a PET tracer).
    FAPI-2 TFA
  • HY-161262
    SB03178
    		Inhibitor
    SB03178 is a fibroblast activation protein-alpha (FAP) inhibitor. SB03178 can be conjugated with DOTA and can be used for cancer research.
    SB03178
  • HY-149860
    FAP-IN-1
    		Inhibitor
    FAP-IN-1 is a fibroblast activation protein (FAP) inhibitor with an IC50 value of 3.3 nM. FAP-IN-1 can be used for the research of cancer.
    FAP-IN-1
  • HY-146180
    FSDD0I
    FSDD0I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD0I can be labeled with 68Ga and 177Lu for single photon emission computed tomography (SPECT) imaging.
    FSDD0I
  • HY-146181
    FSDD1I
    FSDD1I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD1I can be labeled with 68Ga and 177Lu for single photon emission computed tomography (SPECT) imaging.
    FSDD1I
  • HY-103323
    Fas C-Terminal Tripeptide
    		Inhibitor
    Fas C-Terminal Tripeptide is a C-terminal tripeptide of Fas. Fas C-Terminal Tripeptide shows the inhibitory effect on Fas/FAP-1 binding.
    Fas C-Terminal Tripeptide
  • HY-148361
    Fluorogen binding modulator-1
    Fluorogen binding modulator-1 (PubChem SID 125240934) is a fluorogen activating protein (FAP)-fluorogen binding modulator with -log EC50s of 6.61 and 6.37 for AM2.2-β2AR and AM2.2-GPR32, respectively.
    Fluorogen binding modulator-1
  • HY-146182
    FSDD3I
    FSDD3I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD3I can be labeled with 68Ga and 177Lu for single photon emission computed tomography (SPECT) imaging.
    FSDD3I
  • HY-P3392
    Zilganersen
    Zilganersen (ION373) is a glial fibrillary acidic protein (GFAP) inhibitor, an antisense oligonucleotide. Zilganersen can be used in Alexander disease (AxD) research.
    Zilganersen
  • HY-164364B
    DOTAGA.(SA.FAPi)2 analogue TFA
    		Inhibitor
    DOTAGA.(SA.FAPi)2 analogue TFA is a DOTAGA.(SA.FAPi)2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA.(SA.FAPi)2 TFA. DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi).
    DOTAGA.(SA.FAPi)2 analogue TFA
  • HY-163079
    AlF-PD-FAPI
    AlF-PD-FAPI has affinity for FAP , with the IC50 of 0.13 nM, and shows a specific uptake, high internalized fraction, and low cellular efflux in vitro. AlF-PD-FAPI can be used as FAP-targeting tracer.
    AlF-PD-FAPI
Cat. No. Product Name / Synonyms Application Reactivity