iGluR

Ionotropic glutamate receptors

iGluR

iGluR Isoform Specific Products:

iGluR Isoform Comparison

iGluR Related Products (589)
Antibodies (11)
iGluR Isoform Comparison

By Effects:	Controls (2) Ligand (1) Inhibitors (89) Agonists (90) Antagonists (262) Activators (17) Modulators (60) MDM2 Inhibitor (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B1618

Corticosterone	Agonist	99.76%
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.

HY-15084

Dizocilpine maleate	Antagonist	99.99%
Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with K_d of 37.2 nM in rat brain membranes.

HY-14608

L-Glutamic acid	Agonist	99.93%
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.

HY-100714A

D-AP5	Antagonist	99.94%
D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a K_d of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors.

HY-B1102

Evans Blue	Inhibitor
Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability.

HY-B0591

Memantine	Antagonist	99.81%
Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD).

HY-170410

EMD-95885	Antagonist	98.74%
EMD-95885 is a selective NR2B-containing NMDA receptors antagonist with an IC₅₀ of 3.9 nM. EMD-95885 does not interact with other sites on the NMDA receptor. X

HY-15086

Selfotel	Antagonist	99.67%
Selfotel (CGS 19755) is a selective and competitive antagonist at N-methyl-D-aspartate (NMDA)-preferring receptor. CGS 19755 inhibits the binding of [3H]-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to NMDA-type receptors with an IC₅₀ of 50 nM.

HY-17551

NMDA	Agonist	99.73%
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

HY-Y0966

Glycine		99.93%
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis.

HY-N0215

L-Phenylalanine	Antagonist	99.98%
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

HY-15066

CNQX	Antagonist	99.65%
CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats.

HY-100806

Kynurenic acid	Antagonist	99.21%
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.

HY-100807

Quinolinic acid	Agonist	99.85%
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.

HY-15068

NBQX	Antagonist	99.82%
NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity.

HY-30008

Cycloleucine	Antagonist	≥98.0%
Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a K_i of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects.

HY-14608A

L-Glutamic acid monosodium salt	Agonist	≥98.0%
L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases. L-Glutamic acid monosodium salt acts at ionotropic and metabotropic glutamate receptors.

HY-B0030

D-Cycloserine	Agonist	99.97%
D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research.

HY-100714

DL-AP5	Antagonist	≥98.0%
DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina.

HY-12882A

Ifenprodil tartrate	Antagonist	99.95%
Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM). Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator.

Dizocilpine maleate	NMDA Receptor		99.99%
D-AP5	NMDA Receptor		99.94%
EMD-95885	NR2B, IC₅₀: 3.9 nM		98.74%
NMDA	NMDA Receptor		99.73%
Glycine	NMDA Receptor		99.93%
L-Phenylalanine	NMDA Receptor		99.98%
CNQX		Kainate Receptor	99.65%
Kynurenic acid	NMDA Receptor		99.21%
Quinolinic acid	NMDA Receptor		99.85%
Cycloleucine	NMDA Receptor		≥98.0%
D-Cycloserine	NMDA Receptor		99.97%
DL-AP5	NMDA Receptor		≥98.0%
Ifenprodil tartrate	NMDA Receptor		99.95%
DNQX		Kainate Receptor	99.26%
L-Phenylalanine-d₅	NMDA Receptor		99.90%
Topiramate		Kainate Receptor	≥98.0%
Bupivacaine	NMDA Receptor		99.96%
Dizocilpine	NMDA Receptor		99.90%
24-Hydroxycholesterol	NMDA Receptor		99.90%
Quinolinic acid-d₃	NMDA Receptor		99.90%
D-Serine	NMDA Receptor		≥98.0%
Ibotenic acid	NMDA Receptor		99.0%
Crocetin	NMDA Receptor		98.22%
(-)-Huperzine A	NMDA Receptor		99.74%
Ro 25-6981 Maleate	NMDA Receptor		99.25%
PEAQX tetrasodium hydrate	NMDA Receptor		≥98.0%
Bupivacaine hydrochloride	NMDA Receptor		99.89%
Flupirtine Maleate	NMDA Receptor		99.97%
Kynurenic acid-d₅	NMDA Receptor		98.35%
Tacrine hydrochloride	NMDA Receptor		99.95%
Traxoprodil	NMDA Receptor		99.88%
Diphenhydramine	NMDA Receptor, IC₅₀: 24.6 μM		99.08%
Linalool	NMDA Receptor		98.55%
Tat-NR2B9c	NMDA Receptor		99.97%
CNQX disodium		Kainate Receptor	99.95%
MDL-29951	NMDA Receptor		99.17%
ZL006	NMDA Receptor		99.23%
Kynurenic acid sodium	NMDA Receptor		99.79%
24(S)-Hydroxycholesterol	NMDA Receptor		99.55%
MDL 105519	NMDA Receptor		99.67%
7-Chlorokynurenic acid	NMDA Receptor		99.86%
GNE 5729	NMDA Receptor		99.50%
Glycine-d₅	NMDA Receptor		≥99.0%
Indole-2-carboxylic acid	NMDA Receptor		99.86%
Orphenadrine citrate	NMDA Receptor, Ki: 6 μM		99.41%
Rapastinel Trifluoroacetate	NMDA Receptor		≥98.0%
GYKI 52466 dihydrochloride		Kainate Receptor, IC₅₀: 11 μM	99.75%
Glycine-d₂	NMDA Receptor		≥99.0%
TCN 201	NMDA Receptor		99.06%
L-Phenylalanine-d₈	NMDA Receptor		99.62%
Felbamate	NMDA Receptor		99.27%
SYM 2081		Kainate Receptor	≥98.0%
CIQ	NMDA Receptor		99.75%
L-Glutamic acid-¹⁵N	NMDA Receptor		≥98.0%
5,7-Dichlorokynurenic acid	NMDA Receptor		99.91%
Isoxsuprine hydrochloride	NMDA Receptor		99.95%
7-Chlorokynurenic acid sodium salt	NMDA Receptor		99.79%
L-Glutamic acid-¹³C₅	NMDA Receptor		≥98.0%
Glycine-¹³C₂	NMDA Receptor		99.10%
Glycine-1-¹³C	NMDA Receptor		99.4%
Dynorphin A (1-10) (TFA)	NMDA Receptor
Procyclidine hydrochloride	NMDA Receptor		99.55%
L-701324	NMDA Receptor		99.85%
Crocetin disodium	NMDA Receptor		98.00%
L-Phenylalanine-¹³C₆	NMDA Receptor		≥99.0%
Glycine-¹⁵N	NMDA Receptor		≥98.0%
Pulchinenoside A	NMDA Receptor		≥98.0%
Glycine-2-¹³C	NMDA Receptor		99.3%
Nelonemdaz	NMDA Receptor		99.84%
Tat-NR2B9c TFA	NMDA Receptor		99.67%
Glycine-¹³C₂,¹⁵N	NMDA Receptor		≥99.0%
IC87201	NMDA Receptor
Ro 25-6981	NMDA Receptor		99.55%
Plazinemdor	NMDA Receptor
L-Phenylalanine-d₂	NMDA Receptor		99.00%
L-Phenylalanine-¹³C₉	NMDA Receptor		98.09%
Lanicemine dihydrochloride	NMDA Receptor		99.94%
Flupirtine	NMDA Receptor		99.98%
Nelonemdaz potassium	NMDA Receptor		99.86%
NYX-2925	NMDA Receptor		98.77%
L-Phenylalanine-3-¹³C	NMDA Receptor		99.48%
QNZ46	NMDA Receptor		99.46%
Perzinfotel	NMDA Receptor		99.43%
Eliprodil	NMDA Receptor		99.43%
CGP 78608 hydrochloride	NMDA Receptor		99.56%
Brophenexin free base	NMDA Receptor		99.24%
Crocetin meglumine	NMDA Receptor		98.17%
Mephenesin	NMDA Receptor		99.69%
Bupivacaine-d₉	NMDA Receptor		99.04%
SDZ 220-581	NMDA Receptor		99.20%
Budipine	NMDA Receptor		99.41%
L-Homocysteic acid	NMDA Receptor, EC₅₀: 14 μM		≥98.0%
6-Methoxy-2-naphthoic acid	NMDA Receptor		99.73%
(R)-CPP	NMDA Receptor		98.99%
GNE-0723	NMDA Receptor		98.74%
L-Phenylalanine-¹³C₉,¹⁵N	NMDA Receptor		99.52%
Aptiganel hydrochloride	NMDA Receptor		99.80%
L-Phenylalanine-¹³C	NMDA Receptor		99.66%
4-PPBP maleate	NMDA Receptor		99.63%
Tat-NR2Baa	NMDA Receptor
L-Phenylalanine-¹⁵N,d₈	NMDA Receptor		99.90%
L-701252	NMDA Receptor		99.86%
Isoxsuprine-d₆ hydrochloride	NMDA Receptor		99.73%
Withanone	NMDA Receptor
(S)-Willardiine		Kainate Receptor	99.27%
Felbamate-d₄	NMDA Receptor		99.00%
PEAQX	NMDA Receptor
Remacemide	NMDA Receptor
L-Phenylalanine-d₇	NMDA Receptor		99.90%
CGP 37849	NMDA Receptor		≥99.0%
Gavestinel sodium salt	NMDA Receptor		99.38%
(RS)-(Tetrazol-5-yl)glycine	NMDA Receptor
Topiramate D12		Kainate Receptor	99.90%
UBP608	NMDA Receptor		99.60%
TCN 213	NMDA Receptor		99.16%
L-689560	NMDA Receptor		≥99.0%
MRZ 2-514	NMDA Receptor
(S)-(-)-HA 966	NMDA Receptor		≥98.0%
1-Aminocyclobutanecarboxylic acid	NMDA Receptor		≥98.0%
Orphenadrine hydrochloride	NMDA Receptor, Ki: 6 μM
DL-AP5 sodium	NMDA Receptor		99.20%
Midafotel	NMDA Receptor, : 39 nM		99.00%
D-Cycloserine (Standard)	NMDA Receptor
Delucemine	NMDA Receptor
GYKI 52466		Kainate Receptor, IC₅₀: 11 μM
Glycine-¹⁵N,d₂	NMDA Receptor
NMDA agonist 2	NR2C, EC₅₀: 0.034 μM
Ro 04-5595 hydrochloride	GluN2B, Ki: 31 nM
(3S,6R)-NML	GluN2A, IC₅₀: 15.8 μM GluN2B, IC₅₀: 25.1 μM NR2C, IC₅₀: 10 μM NR2D, IC₅₀: 10 μM
PMPA (NMDA antagonist)	NMDA Receptor
NMDAR/HDAC-IN-1	NMDA Receptor, Ki: 0.59 μM
Linalool (Standard)	NMDA Receptor
Analgesic/antidepressant agent-1	NMDA Receptor
(R)-(+)-HA-966	NMDA Receptor		98.85%
L-Phenylalanine-d	NMDA Receptor
HSD17B13-IN-7	NR2B
YY-23	NMDA Receptor
Glycine-d₃	NMDA Receptor
L-Cysteine S-sulfate	NMDA Receptor
L-Glutamic acid-¹³C	NMDA Receptor
L-Phenylalanine-¹³C₉,¹⁵N,d₈	NMDA Receptor
NMDA receptor potentiator-1	NR2C, IC₅₀: 4 μM NR2D, IC₅₀: 5 μM
Bupivacaine (hydrochloride) (Standard)	NMDA Receptor		99.99%
Indole-2-carboxylic acid-¹³C	NMDA Receptor
L-Glutamic acid-1-¹³C	NMDA Receptor		≥99.0%
NMDA agonist 1	NMDA Receptor, Ki: 96 nM
NMDA receptor antagonist-3	NMDA Receptor
UK-240455	NMDA Receptor
Glycine-2-¹³C,¹⁵N	NMDA Receptor		≥98.0%
L-Glutamic acid-5-¹³C	NMDA Receptor
L-AP5	NMDA Receptor
Bupivacaine hydrochloride monohydrate	NMDA Receptor
cis-ACPD	NMDA Receptor, IC₅₀: 3.3 μM
NMDA receptor antagonist 5	NMDA Receptor
Dynorphin A (1-10)	NMDA Receptor
GluN2B-NMDAR antagonist-2	GluN2B, IC₅₀: 74.01 nM
Conantokin G	NMDA Receptor
DL-AP7	NMDA Receptor
Tat-NR2Baa TFA	NMDA Receptor
Procyclidine	NMDA Receptor
GV-196771A	NMDA Receptor
CGP 31358	NMDA Receptor
LY 233053	NMDA Receptor
Orphenadrine-d₃ citrate	NMDA Receptor
GluN2A Allosteric modulator 1	GluN2A, IC₅₀: 0.042 μM GluN2B, IC₅₀: 13 μM
Flupirtine-d4 hydrochloride	NMDA Receptor
MPX-004	NMDA Receptor
GNE 6901	GluN2A, EC₅₀: 382 nM
Antidepressant agent 8	NMDA Receptor, IC₅₀: 2.94 μg/mL
Glycine-1-¹³C,¹⁵N	NMDA Receptor		99.5%
DL-AP5 lithium	NMDA Receptor
Delucemine hydrochloride	NMDA Receptor
NMDAR antagonist 3	NR2B

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iGluR

iGluR

iGluR Isoform Specific Products:

iGluR Isoform Specific Products:

iGluR Related Products (589)

Antibodies (11)

iGluR Isoform Comparison

iGluR Related Products (589):