2. Metabolic Enzyme/Protease Autophagy
  3. Amylases Lipase Autophagy
  4. Dehydrocholate sodium

Dehydrocholate sodium  (Synonyms: Sodium dehydrocholate)

Cat. No.: HY-B0998 Purity: 98.01%
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Dehydrocholate sodium is an orally active hydrocholeretic agent. Dehydrocholate sodium modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholate sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholate sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice.

For research use only. We do not sell to patients.

Dehydrocholate sodium Chemical Structure

Dehydrocholate sodium Chemical Structure

CAS No. : 145-41-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Dehydrocholate sodium:

Dehydrocholate sodium Related Antibodies

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Description

Dehydrocholate sodium is an orally active hydrocholeretic agent. Dehydrocholate sodium modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholate sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholate sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice[1][2][3][4][5].

In Vitro

Dehydrocholate sodium (Dehydrocholic acid; 50-200 μM; 50 min) reduces the necrosis of pancreatic acinar cells induced by sodium Taurocholate (HY-N0545)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dehydrocholate sodium Related Antibodies
In Vivo

Dehydrocholate sodium (Dehydrocholic acid; 25-50 mg/kg; i.p.; 1, 3 and 6 h after the surgery for 3 times) alleviates the severity of Sodium taurocholate-induced acute biliary pancreatitis in C57BL/6 mice, reducing pancreatic histopathological alterations, serum amylase and lipase levels, and suppressing pancreatic trypsin and MPO activities[1].
Dehydrocholate sodium (1-4 μmol/min/100g BW; intravenous infusion) increases bile flow and reduces the secretion of endogenous and exogenous biliary bile acids and biliary lipids in rats[2].
Dehydrocholate sodium (Dehydrocholic acid; 100 mg/kg; p.o. via water bottles) shows choleretic and mild hepatoprotective effects in albino rats with obstructive jaundice[3].
Dehydrocholate sodium (0.4% in diet; p.o.; 1 week) increases liver cholesterol level, bile flow and biliary lipid secretion in rats, and its biological effect is similar to that of cholate[4].
Dehydrocholate sodium (50 mg/kg initial dose, then 167 mg/kg/hr infusion; i.v. and infusion) increases bile flow but does not affect the biliary excretion of methylmercury in rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino rats (100-150 g), obstructive jaundice model induced by ligating the common bile ducts[3]
Dosage: 100 mg/kg
Administration: Oral gavage (p.o.), via water bottles
Result: Led to more marked bile duct dilatation compared to the control group.
Had a choleretic effect, increasing bile volume.
Showed milder liver damage compared to the control group, with marked sinusoidal dilatation and scattered bile lakes.
Had some degree of hepatocyte vacuolation at 4-5 weeks after ligation.
Molecular Weight

424.51

Formula

C24H33NaO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](CCC(O[Na])=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])C(C[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC2=O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (117.78 mM; Need ultrasonic)

DMSO : 20.83 mg/mL (49.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3557 mL 11.7783 mL 23.5566 mL
5 mM 0.4711 mL 2.3557 mL 4.7113 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (78.51 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.3557 mL 11.7783 mL 23.5566 mL 58.8914 mL
5 mM 0.4711 mL 2.3557 mL 4.7113 mL 11.7783 mL
10 mM 0.2356 mL 1.1778 mL 2.3557 mL 5.8891 mL
15 mM 0.1570 mL 0.7852 mL 1.5704 mL 3.9261 mL
20 mM 0.1178 mL 0.5889 mL 1.1778 mL 2.9446 mL
25 mM 0.0942 mL 0.4711 mL 0.9423 mL 2.3557 mL
30 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9630 mL
40 mM 0.0589 mL 0.2945 mL 0.5889 mL 1.4723 mL
H2O 50 mM 0.0471 mL 0.2356 mL 0.4711 mL 1.1778 mL
60 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
80 mM 0.0294 mL 0.1472 mL 0.2945 mL 0.7361 mL
100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5889 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dehydrocholate sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dehydrocholate145-41-5Sodium dehydrocholateAmylasesLipaseAutophagyC57BL/6acute biliary pancreatitischoleretichepatoprotectiveratsInhibitorinhibitorinhibit

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