Lipstatin

Cat. No.: HY-N2330 Purity: ≥80.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM).

For research use only. We do not sell to patients.

Lipstatin Chemical Structure

CAS No. : 96829-59-3

Size	Price	Stock	Quantity
10 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 96	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 155	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Purity & Documentation
References
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Description

Molecular Weight

491.70

Formula

C₂₉H₄₉NO₅

CAS No.

96829-59-3

Appearance

Liquid (Density: 0.993±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

CC(C)C[C@@H](C(O[C@H](C[C@@H]([C@@H]1CCCCCC)OC1=O)C/C=C\C/C=C\CCCCC)=O)NC=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Streptomyces

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (406.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0338 mL	10.1688 mL	20.3376 mL
5 mM	0.4068 mL	2.0338 mL	4.0675 mL
10 mM	0.2034 mL	1.0169 mL	2.0338 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥80.0%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (244 KB) HNMR (297 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Hochuli E, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation. J Antibiot (Tokyo). 1987 Aug;40(8):1086-91. [Content Brief]

[2]. Weibel EK, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. J Antibiot (Tokyo). 1987 Aug;40(8):1081-5. [Content Brief]

[3]. Weibel E K, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini I. Producing organism, fermentation, isolation and biological activity[J]. The Journal of antibiotics, 1987, 40(8): 1081-1085.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0338 mL	10.1688 mL	20.3376 mL	50.8440 mL
	5 mM	0.4068 mL	2.0338 mL	4.0675 mL	10.1688 mL
	10 mM	0.2034 mL	1.0169 mL	2.0338 mL	5.0844 mL
	15 mM	0.1356 mL	0.6779 mL	1.3558 mL	3.3896 mL
	20 mM	0.1017 mL	0.5084 mL	1.0169 mL	2.5422 mL
	25 mM	0.0814 mL	0.4068 mL	0.8135 mL	2.0338 mL
	30 mM	0.0678 mL	0.3390 mL	0.6779 mL	1.6948 mL
	40 mM	0.0508 mL	0.2542 mL	0.5084 mL	1.2711 mL
	50 mM	0.0407 mL	0.2034 mL	0.4068 mL	1.0169 mL
	60 mM	0.0339 mL	0.1695 mL	0.3390 mL	0.8474 mL
	80 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6356 mL
	100 mM	0.0203 mL	0.1017 mL	0.2034 mL	0.5084 mL

Lipstatin Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipstatin96829-59-3LipaseInhibitorinhibitorinhibit

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