2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Nuclear Hormone Receptor 4A/NR4A

Nuclear Hormone Receptor 4A/NR4A

Nuclear Hormone Receptor 4A; Nerve Growth Factor IB-like Receptor

Nuclear Hormone Receptor 4A (NR4A) belongs to the nuclear receptor (NR) superfamily and comprises three members: NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1), all of which are classified as "orphan receptors" (without a clearly defined natural ligand). NR4A plays pivotal roles in various cell types, including proliferation, apoptosis, DNA repair, cellular stress, memory, endocrinology, neuronal signaling, as well as hematopoietic, immune, and metabolic processes. Furthermore, NR4A is implicated in the pathogenesis and progression of numerous diseases, such as obesity, vascular diseases, inflammation, metabolic disorders, and neurodegenerative diseases[1][2][3][4].

Nuclear Hormone Receptor 4A/NR4A Isoform Specific Products:

Nuclear Hormone Receptor 4A/NR4A Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-149608
    Nurr1 agonist 5
    		Agonist
    Nurr1 agonist 5 (compound 5o) is a neuroprotective transcription factor Nurr1 agonist with a Kd of 0.5 μM and an EC50 of 3 μM.
    Nurr1 agonist 5
  • HY-B1322R
    Amodiaquine (dihydrochloride dihydrate) (Standard)
    		Agonist
    Amodiaquine (dihydrochloride dihydrate) (Standard) is the analytical standard of Amodiaquine (dihydrochloride dihydrate). This product is intended for research and analytical applications. Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.
    Amodiaquine (dihydrochloride dihydrate) (Standard)
  • HY-N2148R
    Cytosporone B (Standard)
    		Agonist
    Cytosporone B (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Nuclear Hormone Receptor 4A/NR4A Isoform Comparison

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.