2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Nuclear Hormone Receptor 4A/NR4A
  5. Nuclear Hormone Receptor 4A/NR4A Isoform

Nuclear Hormone Receptor 4A/NR4A

 

Nuclear Hormone Receptor 4A/NR4A Related Products (16):

Cat. No. Product Name Effect Purity
  • HY-110329
    ML179
    		99.83%
    ML179 (SR-1309) is a inverse LRH1 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer.
  • HY-U00429
    NOT Receptor Modulator 1
    		Modulator 98.61%
    NOT Receptor Modulator 1 is a nuclear receptor NOT modulator extracted from patent WO 2008034974 A1, Example 39 in table1.
  • HY-149867
    Nurr1 agonist 4
    		Agonist 98.74%
    Nurr1 agonist 4 (compound 8) is a high-affinity Nurr1 agonist with EC50 of 2.1 μM.
  • HY-W270810
    Nurr1 agonist 8
    		99.93%
    Nurr1 agonist 8 (compound 111) is a Nurr1 agonist with an EC50 value of 0.09 μM.
  • HY-149609
    Nurr1 agonist 6
    		Agonist
    Nurr1 agonist 6 (compound 13) is a Nurr1 agonist with Kd value of 1.5 μM and EC50 value of 3 μM.
  • HY-162786
    Nurr1 agonist 11
    		Agonist
    Nurr1 agonist 11 (compound 53) is a selective and potent Nurr1 agonist with an IC50 of 26 µM. Nurr1 agonist 11 has the ability to cross a cellular model of the blood-brain-barrier (BBB) .
  • HY-159779
    NR-V04
    		Degrader
    NR-V04 is a PROTAC based NR4A1 degrader (Red: NR4A1 inhibitor (HY-13067), black: linker, Blue: E3 ligase ligand).
  • HY-169906
    Anticancer agent 257
    		Modulator
    Anticancer agent 257 (compound of formula (I)) is an anticancer agent with Nur77 and Nurrl modulating effects.
  • HY-131486
    Digoxigenin bisdigitoxoside
    		Control
    Digoxigenin bisdigitoxoside is an anticancer drug. Digoxigenin bisdigitoxoside is cytotoxic.
  • HY-P1624A
    Teduglutide TFA
    		Activator
    Teduglutide TFA is a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analogue. Teduglutide TFA can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide TFA can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis.
  • HY-157807
    Prostaglandin E2-biotin
    		≥99.0%
    Prostaglandin E2-biotin is a prostaglandin analog. Prostaglandin E2-biotin can be used for research of Nurr1-related disease, such as cancer and autoimmune disease.
  • HY-157026
    Nurr1 agonist 7
    		Agonist 99.90%
    Nurr1 agonist 7 (compound 110) is a Nurr1 agonist with an EC50 value of 0.12 μM.
  • HY-B1322AS1
    Amodiaquine-d10 hydrochloride
    		Agonist
    Amodiaquine-d10 hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.
  • HY-119971
    BIM5078
    		Antagonist
    BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes.
  • HY-160498
    Amoitone B
    		Agonist
    Amoitone B, a derivative of cystosporone B, is an agonist of NR4A1. Amoitone B has anticancer activity.
  • HY-B1322R
    Amodiaquine (dihydrochloride dihydrate) (Standard)
    		Agonist
    Amodiaquine (dihydrochloride dihydrate) (Standard) is the analytical standard of Amodiaquine (dihydrochloride dihydrate). This product is intended for research and analytical applications. Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.