2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Nuclear Hormone Receptor 4A/NR4A
  5. Nurr1/NR4A2 Isoform
  6. Nurr1/NR4A2 Agonist

Nurr1/NR4A2 Agonist

Nurr1/NR4A2 Agonists (9):

Cat. No. Product Name Effect Purity
  • HY-B1322A
    Amodiaquine
    		Agonist 99.98%
    Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.
  • HY-B1322
    Amodiaquine dihydrochloride dihydrate
    		Agonist 99.89%
    Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.
  • HY-B1322B
    Amodiaquine dihydrochloride
    		Agonist 99.89%
    Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a Ki of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.
  • HY-163801
    Nurr1 agonist 9
    		Agonist
    Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC50 of 0.090 µM and a Kd of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC50=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC50=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable.
  • HY-163802
    Nurr1 agonist 10
    		Agonist
    Nurr1 agonist 10 (compound 37) is a potent Nurr1 agonist with an EC50 value of 40 nM. Nurr1 agonist 10 has the potential for the research of Parkinson’s and Alzheimer’s disease.
  • HY-132909
    Nurr1 inverse agonist-1
    		Agonist 99.79%
    Nurr1 inverse agonist-1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1.
  • HY-W677684
    Nurr1 agonist 2
    		Agonist 99.27%
    Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC50: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a Kd value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression.
  • HY-155659
    4A7C-301
    		Agonist 98.8%
    4A7C-301 is a Nurr1 agonist with robust neuroprotective effects in vitro. 4A7C-301 significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models. 4A7C-301 can be used for the research of Parkinson’s disease.
  • HY-149608
    Nurr1 agonist 5
    		Agonist
    Nurr1 agonist 5 (compound 5o) is a neuroprotective transcription factor Nurr1 agonist with a Kd of 0.5 μM and an EC50 of 3 μM.