Nurr1 inverse agonist-1

Name: Nurr1 inverse agonist-1
Brand: MedChemExpress
SKU: HY-132909
Rating: 4.5 (1 reviews)

Cat. No.: HY-132909 Purity: 99.79%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Nurr1 inverse agonist-1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1.

For research use only. We do not sell to patients.

Nurr1 inverse agonist-1 Chemical Structure

CAS No. : 2758673-07-1

Size	Price	Stock	Quantity
5 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1230	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Nurr1/NR4A2 Nur77/NR4A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Nurr1 inverse agonist-1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1.

IC₅₀ & Target

Nurr1/NR4A2

Molecular Weight

266.29

Formula

C₁₆H₁₄N₂O₂

CAS No.

2758673-07-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CN(C2=CC=C(C=C21)C3=CC=CN=C3)C)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (375.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7553 mL	18.7765 mL	37.5530 mL
5 mM	0.7511 mL	3.7553 mL	7.5106 mL
10 mM	0.3755 mL	1.8777 mL	3.7553 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (9.39 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (9.39 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (9.39 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.79%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (252 KB) HNMR (118 KB) RP-HPLC (139 KB) LCMS (235 KB)

Handling Instructions (2659 KB)

References

[1]. Zaienne D, et al. Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1. J Med Chem. 2021 Oct 28;64(20):15126-15140. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7553 mL	18.7765 mL	37.5530 mL	93.8826 mL
	5 mM	0.7511 mL	3.7553 mL	7.5106 mL	18.7765 mL
	10 mM	0.3755 mL	1.8777 mL	3.7553 mL	9.3883 mL
	15 mM	0.2504 mL	1.2518 mL	2.5035 mL	6.2588 mL
	20 mM	0.1878 mL	0.9388 mL	1.8777 mL	4.6941 mL
	25 mM	0.1502 mL	0.7511 mL	1.5021 mL	3.7553 mL
	30 mM	0.1252 mL	0.6259 mL	1.2518 mL	3.1294 mL
	40 mM	0.0939 mL	0.4694 mL	0.9388 mL	2.3471 mL
	50 mM	0.0751 mL	0.3755 mL	0.7511 mL	1.8777 mL
	60 mM	0.0626 mL	0.3129 mL	0.6259 mL	1.5647 mL
	80 mM	0.0469 mL	0.2347 mL	0.4694 mL	1.1735 mL
	100 mM	0.0376 mL	0.1878 mL	0.3755 mL	0.9388 mL