2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. Nurr1 agonist 2

Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC50: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a Kd value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression.

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Nurr1 agonist 2 Chemical Structure

Nurr1 agonist 2 Chemical Structure

CAS No. : 742058-34-0

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Nurr1 agonist 2 Related Antibodies

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Nurr1/NR4A2 Nur77/NR4A1

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Description

Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC50: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a Kd value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression[1].

IC50 & Target

Nurr1/NR4A2

 

Molecular Weight

310.37

Formula

C18H14O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=C(C2=CC=C(C=C2)OCC3=CC=CC=C3)S1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (67.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2220 mL 16.1098 mL 32.2196 mL
5 mM 0.6444 mL 3.2220 mL 6.4439 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2220 mL 16.1098 mL 32.2196 mL 80.5490 mL
5 mM 0.6444 mL 3.2220 mL 6.4439 mL 16.1098 mL
10 mM 0.3222 mL 1.6110 mL 3.2220 mL 8.0549 mL
15 mM 0.2148 mL 1.0740 mL 2.1480 mL 5.3699 mL
20 mM 0.1611 mL 0.8055 mL 1.6110 mL 4.0275 mL
25 mM 0.1289 mL 0.6444 mL 1.2888 mL 3.2220 mL
30 mM 0.1074 mL 0.5370 mL 1.0740 mL 2.6850 mL
40 mM 0.0805 mL 0.4027 mL 0.8055 mL 2.0137 mL
50 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.6110 mL
60 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3425 mL
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Nurr1 agonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nurr1 agonist 2742058-34-0Nuclear Hormone Receptor 4A/NR4ANerve Growth Factor IB-like ReceptorCLMschemical language modelNurr1 Agonisttyrosine hydroxylaseVMAT2Inhibitorinhibitorinhibit

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