2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Kinase
  5. Ser/Thr Kinase Inhibitor

Ser/Thr Kinase Inhibitor

Ser/Thr Kinase Inhibitors (18):

Cat. No. Product Name Effect Purity
  • HY-161111
    KVS0001
    		Inhibitor 99.14%
    KVS0001 is a potent inhibitor of SMG1 and nonsense mediated decay (NMD) that has anti-tumor activity.
  • HY-132868
    SLK/STK10-IN-1
    		Inhibitor 99.34%
    SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.
  • HY-103020
    BAY-1816032
    		Inhibitor 99.05%
    BAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM.
  • HY-104001
    BAY-524
    		Inhibitor 99.48%
    BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents.
  • HY-147655
    CQ211
    		Inhibitor 99.58%
    CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines.
  • HY-12240
    B32B3
    		Inhibitor
    B32B3 is an inhibitor of VprBP with an IC50 value of 0.5 μM at the H2AT120p cell. B32B3 can suppress tumor growth.
  • HY-10424A
    Milciclib maleate
    		Inhibitor
    Milciclib (PHA-848125) maleate is a cyclin-dependent kinase inhibitor that impairs melanoma cell growth and modulates gene expression involved in cell cycle regulation. Milciclib maleate has been shown to significantly affect the expression of various genes, including down-regulating PTTG1, contributing to its antiproliferative activity. Milciclib maleate enhances sensitivity to treatment in p53 mutated melanoma cells when combined with PTTG1 silencing.
  • HY-145725A
    Baliforsen
    		Inhibitor
    Baliforsen is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.
  • HY-162426
    UNC-CA2-103
    		Inhibitor 99.26%
    UNC-CA2-103 (compound 128) is a potent inhibitor of Tousled like kinase 2 (TLK2), with the IC50 of 18 nM.
  • HY-116559
    TIBI
    		Inhibitor 99.62%
    TIBI is a potent and ATP-competitive inhibitor of Rio1 (IC50: 0.09 μM, Ki: 0.05 μM). TIBI enhances the thermostability of the enzyme Rio1.
  • HY-115719
    CASK-IN-1
    		Inhibitor 99.7%
    CASK-IN-1 is a highly potent and selective CASK inhibitor with a Kd value of 0.022 μM.
  • HY-156792
    RIOK2-IN-1
    		Inhibitor
    RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression.
  • HY-171294
    Protein kinase inhibitor 16
    		Inhibitor
    Protein kinase inhibitor 16 exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase.
  • HY-171276
    Anti-neuroinflammation agent 3
    		Inhibitor
    Anti-neuroinflammation agent 3 (Compound A.10.3) exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase.
  • HY-171291
    Protein kinase inhibitor 14
    		Inhibitor
    Protein kinase inhibitor 14 (Compound 13) exhibits inhibitory effects against a variety of serine/threonine kinase and receptor/non-receptor tyrosine kinase.
  • HY-169587
    Protein kinase G inhibitor-3
    		Inhibitor
    Protein kinase G inhibitor-3 (Compound 177) is an inhibitor of mycobacterial serine/threonine protein kinases. Protein kinase G inhibitor-3 can be used in the research of diseases related to mycobacterial infections.
  • HY-171293
    Protein kinase inhibitor 15
    		Inhibitor
    Protein kinase inhibitor 15 (Compound A.35.3) exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase.
  • HY-156465
    RIOK2-IN-2
    		Inhibitor
    RIOK2-IN-2 (8) is a RIOK2 inhibitor, with IC50 values of 3.02 μM and 5.34 μM in MKN-1 and MOLT4 cells, respectively.