1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. β-glucuronidase

β-glucuronidase

GUSB

β-glucuronidase is a glycoside hydrolase widely distributed in mammalian tissues, body fluids, microbiota, plants, fish, insects and mollusks. β-glucuronidase belongs to GH family 1, 2, 30, 79, 154 and GH-A. β-glucuronidase can hydrolyze estrogen glucuronides, regulate the enterohepatic circulation and reabsorption of estrogen, and affect estrogen metabolism. β-glucuronidase can also hydrolyze the extracellular sugar residues on the TRPV5 channel, trapping it in the plasma membrane, maintaining calcium channel activity and membrane calcium permeability. This target is related to many disease areas. For example, in cancer, its increased activity is related to the occurrence and development of colorectal cancer, breast cancer, ovarian cancer, etc.; in metabolic diseases, it is related to diabetes and its induced periodontitis; in inflammatory diseases, it involves bacterial peritonitis, bacterial meningitis, pelvic inflammatory disease, etc.; in addition, it is also related to diseases such as endometriosis[1][2][3][4][5][6][7].

β-glucuronidase Related Products (36):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2803
    Beta-glucuronidase (Escherichia coli)
    Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan.
    Beta-glucuronidase (Escherichia coli)
  • HY-134453A
    D-Saccharic acid 1,4-lactone hydrate
    Inhibitor ≥98.0%
    D-Saccharic acid 1,4-lactone hydrate is an orally active β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties.
    D-Saccharic acid 1,4-lactone hydrate
  • HY-D0935A
    4-Methylumbelliferyl-β-D-glucuronide hydrate
    Substrate 99.92%
    4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli.
    4-Methylumbelliferyl-β-D-glucuronide hydrate
  • HY-W039892
    4-Nitrophenyl β-D-glucuronide
    Substrate 99.13%
    4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-Nitrophenol. 4-Nitrophenyl β-D-glucuronide is the chromogenic substrate for β-glucuronidase.
    4-Nitrophenyl β-D-glucuronide
  • HY-103081
    β-Glucuronidase-IN-1
    Inhibitor 99.05%
    β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC50 and a Ki of 283 nM and 164 nM, respectively.
    β-Glucuronidase-IN-1
  • HY-N2998R
    Ganoderenic acid A (Standard)
    Inhibitor
    Carbidopa (monohydrate) (Standard) is the analytical standard of Carbidopa (monohydrate). This product is intended for research and analytical applications. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.
    Ganoderenic acid A (Standard)
  • HY-173397
    β-Glucuronidase-IN-3
    Inhibitor
    β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric β-glucuronidase inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) (IC50: 12.9 nM). β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan (HY-16562) and nonsteroidal anti-inflammatory drugs (NSAIDs).
    β-Glucuronidase-IN-3
  • HY-137783
    Resorufin β-D-glucuronide sodium
    Substrate
    Resorufin β-D-glucuronide sodium can be used as a substrate for β-glucuronidase.
    Resorufin β-D-glucuronide sodium
  • HY-P2803A
    Beta-glucuronidase (bovine liver)
    Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan.
    Beta-glucuronidase (bovine liver)
  • HY-148044
    UNC10201652
    Inhibitor 99.33%
    UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes.
    UNC10201652
  • HY-15935B
    X-Gluc cyclohexanamine
    99.96%
    X-Gluc cyclohexanamine is a dye reagent for the detection of β-glucuronidase (GUS), an enzyme produced by E. coli. X-Gluc cyclohexanamine can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc cyclohexanamine is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue).
    X-Gluc cyclohexanamine
  • HY-W345885
    Saccharic acid
    Inhibitor ≥98.0%
    Saccharic acid is a competitive inhibitor of β-glucuronidase. Saccharic acid considerably retards hydrolysis of the glucuronide of 'l-ortho-hydroxyphenylazo-2-naph-thol' by frozen mouse kidney sections, but has no effect on liver regeneration following damage and on growth in infant mice.
    Saccharic acid
  • HY-N1733
    2′-Hydroxydaidzein
    Inhibitor
    2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively.
    2′-Hydroxydaidzein
  • HY-151168
    3-Chlorogentisyl alcohol
    Inhibitor 99.70%
    3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 μM, an Ki value of 0.58 μM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies.
    3-Chlorogentisyl alcohol
  • HY-15935C
    X-Gluc sodium
    ≥98.0%
    X-Gluc sodium is a dye reagent for the detection of β-glucuronidase (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue).
    X-Gluc sodium
  • HY-N2998
    Ganoderenic acid A
    Inhibitor
    Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury.
    Ganoderenic acid A
  • HY-D0164
    Naphthol AS-BI
    Substrate 99.71%
    Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues.
    Naphthol AS-BI
  • HY-15935
    X-Gluc Dicyclohexylamine
    99.48%
    X-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system).
    X-Gluc Dicyclohexylamine
  • HY-N1735
    2′-Hydroxygenistein
    Inhibitor 99.41%
    2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils, with IC50 values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively.
    2′-Hydroxygenistein
  • HY-150976
    β-Glucuronidase/hCAII-IN-1
    Inhibitor
    β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent β-glucuronidase and hCA II inhibitor with an IC50 of 440.1 μM and 4.91 μM, respectively.
    β-Glucuronidase/hCAII-IN-1