2. Immunology/Inflammation
  3. Interleukin Related
  4. Veledimex (S enantiomer)

Veledimex (S enantiomer)  (Synonyms: INXN-1001 (S enantiomer); RG-115932 (S enantiomer))

Cat. No.: HY-16785B Purity: 99.52% ee.: 99.51%
COA Handling Instructions

Molarity Calculator

Veledimex S enantiomer (INXN-1001 S enantiomer) is the S enantiomer of veledimex. Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5.

For research use only. We do not sell to patients.

Veledimex (S enantiomer) Chemical Structure

Veledimex (S enantiomer) Chemical Structure

CAS No. : 1093131-03-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 814 In-stock
Solution
10 mM * 1 mL in DMSO USD 814 In-stock
Solid
1 mg USD 300 In-stock
5 mg USD 740 In-stock
10 mg USD 1100 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Veledimex (S enantiomer):

Veledimex (S enantiomer) Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Veledimex S enantiomer (INXN-1001 S enantiomer) is the S enantiomer of veledimex. Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5[1].

IC50 & Target

IL-1

 

In Vivo

Veledimex generally has moderate to low oral bioavailability after a single oral administration in mice and monkeys (-56% in mice and up to 17.4% in cynomolgus monkeys) with mostly low plasma clearance (1399 and 1170 mL/h per kilogram in mice and monkeys, respectively), high volume of distribution (20271 and 9180 mL/h per kilogram in mice and monkeys, respectively), and long terminal half-lives (-10 hours in mice and -30 hours in monkeys) after intravenous administration[1]. Ad-RTS-mIL-12 + veledimex have demonstrated a dose-related increase in tumor IL-12 mRNA and IL-12 protein expression. Discontinuation of veledimex resulted in a return to baseline IL-12 mRNA and protein expression in numerous syngeneic mouse tumor models. Veledimex crosses the blood-brain-barrier in both naive and orthotopic GL-261 mice with increased brain tissue level of -6 fold observed in tumor bearing vs. normal mice. Ad-RTS-mIL-12 + veledimex demonstrate a dose-related increase in survival without significant adverse events[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

438.60

Formula

C27H38N2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NN(C(C1=CC(C)=CC(C)=C1)=O)[C@H](C(C)(C)C)CCC)C2=CC=CC(OC)=C2CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (228.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2800 mL 11.3999 mL 22.7998 mL
5 mM 0.4560 mL 2.2800 mL 4.5600 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.52% ee.: 99.51%

COA (256 KB) HNMR (181 KB) LCMS (378 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2800 mL 11.3999 mL 22.7998 mL 56.9995 mL
5 mM 0.4560 mL 2.2800 mL 4.5600 mL 11.3999 mL
10 mM 0.2280 mL 1.1400 mL 2.2800 mL 5.7000 mL
15 mM 0.1520 mL 0.7600 mL 1.5200 mL 3.8000 mL
20 mM 0.1140 mL 0.5700 mL 1.1400 mL 2.8500 mL
25 mM 0.0912 mL 0.4560 mL 0.9120 mL 2.2800 mL
30 mM 0.0760 mL 0.3800 mL 0.7600 mL 1.9000 mL
40 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4250 mL
50 mM 0.0456 mL 0.2280 mL 0.4560 mL 1.1400 mL
60 mM 0.0380 mL 0.1900 mL 0.3800 mL 0.9500 mL
80 mM 0.0285 mL 0.1425 mL 0.2850 mL 0.7125 mL
100 mM 0.0228 mL 0.1140 mL 0.2280 mL 0.5700 mL
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Veledimex (S enantiomer) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Veledimex (S enantiomer)1093131-03-3INXN-1001 (S enantiomer) RG-115932 (S enantiomer)Interleukin RelatedILInhibitorinhibitorinhibit

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