(-)-Sparteine sulfate pentahydrate (Synonyms: (-)-Lupinidine sulfate pentahydrate)

Cat. No.: HY-B1304: FAQs
Data Sheet SDS Handling Instructions

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(-)-Sparteine sulfate pentahydrate ((-)-Lupinidine sulfate pentahydrate) is a class 1a antiarrhythmic agent and a sodium channel blocker.

For research use only. We do not sell to patients.

(-)-Sparteine sulfate pentahydrate Chemical Structure

CAS No. : 6160-12-9

Size	Price	Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO	USD 55	Ask For Quote & Lead Time
Solid
50 mg	USD 50	Ask For Quote & Lead Time

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Other In-stock Forms of (-)-Sparteine sulfate pentahydrate:

(-)-Sparteine

Other Forms of (-)-Sparteine sulfate pentahydrate:

(+)-Sparteine In-stock
(-)-Sparteine In-stock
(+)-Sparteine sulfate pentahydrate Get quote
(-)-Sparteine sulfate Get quote
(-)-Sparteine hydroiodide Get quote

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View All Isoforms

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

Biological Activity
Purity & Documentation
Customer Review

Description

(-)-Sparteine sulfate pentahydrate ((-)-Lupinidine sulfate pentahydrate) is a class 1a antiarrhythmic agent and a sodium channel blocker. It is an alkaloid, can chelate the bivalents calcium and magnesium.

Molecular Weight

422.54

Formula

C₁₅H₃₈N₂O₉S

CAS No.

6160-12-9

Appearance

Solid

SMILES

O=S(O)(O)=O.[H][C@]12C[C@](CN3[C@]2([H])CCCC3)([H])[C@@](CCCC4)([H])N4C1.O.O.O.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (236.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3666 mL	11.8332 mL	23.6664 mL
5 mM	0.4733 mL	2.3666 mL	4.7333 mL
10 mM	0.2367 mL	1.1833 mL	2.3666 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Data Sheet (246 KB) SDS (252 KB) Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3666 mL	11.8332 mL	23.6664 mL	59.1660 mL
	5 mM	0.4733 mL	2.3666 mL	4.7333 mL	11.8332 mL
	10 mM	0.2367 mL	1.1833 mL	2.3666 mL	5.9166 mL
	15 mM	0.1578 mL	0.7889 mL	1.5778 mL	3.9444 mL
	20 mM	0.1183 mL	0.5917 mL	1.1833 mL	2.9583 mL
	25 mM	0.0947 mL	0.4733 mL	0.9467 mL	2.3666 mL
	30 mM	0.0789 mL	0.3944 mL	0.7889 mL	1.9722 mL
	40 mM	0.0592 mL	0.2958 mL	0.5917 mL	1.4791 mL
	50 mM	0.0473 mL	0.2367 mL	0.4733 mL	1.1833 mL
	60 mM	0.0394 mL	0.1972 mL	0.3944 mL	0.9861 mL
	80 mM	0.0296 mL	0.1479 mL	0.2958 mL	0.7396 mL
	100 mM	0.0237 mL	0.1183 mL	0.2367 mL	0.5917 mL

(-)-Sparteine sulfate pentahydrate Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Sparteine sulfate6160-12-9(-)-Lupinidine sulfateSodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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