2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. (+)-Sparteine

(+)-Sparteine  (Synonyms: Pachycarpine)

Cat. No.: HY-W008350 Purity: 99.87%
SDS COA Handling Instructions

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(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.

For research use only. We do not sell to patients.

(+)-Sparteine Chemical Structure

(+)-Sparteine Chemical Structure

CAS No. : 492-08-0

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Liquid
100 mg USD 50 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of (+)-Sparteine:

(+)-Sparteine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (+)-Sparteine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.

IC50 & Target

AChR[1]
In Vitro

(+)-Sparteine (2 μM) reduces the ACh-induced current caused by activation of nicotinic AChRs in a voltage-independent manner. (+)-Sparteine (5, 10 μM) reduces the amplitude of the excitatory postsynaptic current (EPSC) and the time constant of the EPSC decay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-Sparteine Related Antibodies
Molecular Weight

234.38

Formula

C15H26N2
CAS No.
Appearance

Liquid (Density: 1.08 g/cm3)

Color

Colorless to light yellow

SMILES

[H][C@]12CCCCN1C[C@H]3C[C@@H]2CN4CCCC[C@@]34[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (853.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 2.5 mg/mL (10.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2666 mL 21.3329 mL 42.6658 mL
5 mM 0.8533 mL 4.2666 mL 8.5332 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.87%

SDS (393 KB)

COA (255 KB) HNMR (248 KB) RP-HPLC (205 KB) LCMS (78 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.2666 mL 21.3329 mL 42.6658 mL 106.6644 mL
5 mM 0.8533 mL 4.2666 mL 8.5332 mL 21.3329 mL
10 mM 0.4267 mL 2.1333 mL 4.2666 mL 10.6664 mL
DMSO 15 mM 0.2844 mL 1.4222 mL 2.8444 mL 7.1110 mL
20 mM 0.2133 mL 1.0666 mL 2.1333 mL 5.3332 mL
25 mM 0.1707 mL 0.8533 mL 1.7066 mL 4.2666 mL
30 mM 0.1422 mL 0.7111 mL 1.4222 mL 3.5555 mL
40 mM 0.1067 mL 0.5333 mL 1.0666 mL 2.6666 mL
50 mM 0.0853 mL 0.4267 mL 0.8533 mL 2.1333 mL
60 mM 0.0711 mL 0.3555 mL 0.7111 mL 1.7777 mL
80 mM 0.0533 mL 0.2667 mL 0.5333 mL 1.3333 mL
100 mM 0.0427 mL 0.2133 mL 0.4267 mL 1.0666 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(+)-Sparteine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Sparteine492-08-0PachycarpinenAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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