2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. (R)-Baclofen

(R)-Baclofen  (Synonyms: Arbaclofen; STX209)

Cat. No.: HY-17354 Purity: 98.87%
COA Handling Instructions

Molarity Calculator

(R)-Baclofen (Arbaclofen) is a selective GABAB receptor agonist.

For research use only. We do not sell to patients.

(R)-Baclofen Chemical Structure

(R)-Baclofen Chemical Structure

CAS No. : 69308-37-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 45 In-stock
Solution
10 mM * 1 mL in Water USD 45 In-stock
Solid
5 mg USD 41 In-stock
10 mg USD 66 In-stock
50 mg USD 238 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

Other Forms of (R)-Baclofen:

(R)-Baclofen Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(R)-Baclofen (Arbaclofen) is a selective GABAB receptor agonist[1].

IC50 & Target

GABAB receptor[1]
In Vivo

(R)-Baclofen (STX209) suppresses audiogenic seizures in the Fmr1-knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg[5].
Acute intraperitoneal administration of (R)-Baclofen (STX209) significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

213.66

Formula

C10H12ClNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C([C@](CC(O)=O)([H])CN)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (23.40 mM; Need ultrasonic)

DMSO : 1 mg/mL (4.68 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6803 mL 23.4017 mL 46.8033 mL
5 mM 0.9361 mL 4.6803 mL 9.3607 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 4.17 mg/mL (19.52 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.87%

COA (250 KB) HNMR (249 KB) LCMS (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.6803 mL 23.4017 mL 46.8033 mL 117.0083 mL
H2O 5 mM 0.9361 mL 4.6803 mL 9.3607 mL 23.4017 mL
10 mM 0.4680 mL 2.3402 mL 4.6803 mL 11.7008 mL
15 mM 0.3120 mL 1.5601 mL 3.1202 mL 7.8006 mL
20 mM 0.2340 mL 1.1701 mL 2.3402 mL 5.8504 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(R)-Baclofen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Baclofen69308-37-8Arbaclofen STX209STX209STX 209STX-209GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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