(R)-Baclofen (Synonyms: Arbaclofen; STX209)

Name: (R)-Baclofen
Brand: MedChemExpress
SKU: HY-17354
Rating: 5.0 (2 reviews)

Cat. No.: HY-17354 Purity: 99.50%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(R)-Baclofen (Arbaclofen) is a selective GABAB receptor agonist.

For research use only. We do not sell to patients.

(R)-Baclofen Chemical Structure

CAS No. : 69308-37-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 45	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 45	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 41	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 66	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 238	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of (R)-Baclofen:

Baclofen In-stock
(S)-Baclofen Get quote
(R)-Baclofen hydrochloride Get quote

2 Publications Citing Use of MCE (R)-Baclofen

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

(R)-Baclofen (Arbaclofen) is a selective GABAB receptor agonist^[1].

IC₅₀ & Target

GABAB receptor^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	1 μM Compound: (-)-baclofen	Agonist activity at human GABA-B B1/B2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 3 hrs by luciferase reporter gene assay Agonist activity at human GABA-B B1/B2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 3 hrs by luciferase reporter gene assay	[PMID: 23428109]

In Vivo

(R)-Baclofen (STX209) suppresses audiogenic seizures in the Fmr1-knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg^[5].
Acute intraperitoneal administration of (R)-Baclofen (STX209) significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

213.66

Formula

C₁₀H₁₂ClNO₂

CAS No.

69308-37-8

Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C([C@](CC(O)=O)([H])CN)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 5 mg/mL (23.40 mM; Need ultrasonic)

DMSO : 1 mg/mL (4.68 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6802 mL	23.4012 mL	46.8025 mL
5 mM	0.9360 mL	4.6802 mL	9.3605 mL
10 mM	0.4680 mL	2.3401 mL	4.6802 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 4.17 mg/mL (19.52 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.50%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (250 KB) HNMR (243 KB) RP-HPLC (245 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Hong YG, et al. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75. [Content Brief]

[2]. Falch E, et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903. [Content Brief]

[3]. Falch E, et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903. [Content Brief]

[4]. Orsnes G, et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.6802 mL	23.4012 mL	46.8025 mL	117.0061 mL
H₂O	5 mM	0.9360 mL	4.6802 mL	9.3605 mL	23.4012 mL
	10 mM	0.4680 mL	2.3401 mL	4.6802 mL	11.7006 mL
	15 mM	0.3120 mL	1.5601 mL	3.1202 mL	7.8004 mL
	20 mM	0.2340 mL	1.1701 mL	2.3401 mL	5.8503 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(R)-Baclofen Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Baclofen69308-37-8Arbaclofen STX209STX209STX 209STX-209GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

(R)-Baclofen (Synonyms: Arbaclofen; STX209)

Customer Review

Other Forms of (R)-Baclofen:

(R)-Baclofen Related Antibodies

2 Publications Citing Use of MCE (R)-Baclofen

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

(R)-Baclofen Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report