2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. ABBV-712

ABBV-712 is a selective inhibitor of Tyrosine kinase 2 (TYK2), with IC50 of 0.195 μM, that play important role in autoimmune diseases.

For research use only. We do not sell to patients.

ABBV-712 Chemical Structure

ABBV-712 Chemical Structure

CAS No. : 2368945-27-9

Size Price Stock Quantity
1 mg USD 538 In-stock
5 mg USD 1346 In-stock
10 mg USD 2155 In-stock
25 mg USD 4300 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

ABBV-712 Related Antibodies

Top Publications Citing Use of Products

View All JAK Isoform Specific Products:

View All Isoforms
JAK1 JAK2 JAK3 Tyk2 JAK

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ABBV-712 is a selective inhibitor of Tyrosine kinase 2 (TYK2), with IC50 of 0.195 μM, that play important role in autoimmune diseases[1].

IC50 & Target

JAK1

80 μM (IC50)

Molecular Weight

452.50

Formula

C24H28N4O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(NC1=CC2=C(C=N1)N(C=C2C3=NC([C@]4(COCC4)OC)=CC(COC)=C3)C5COC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (552.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2099 mL 11.0497 mL 22.0994 mL
5 mM 0.4420 mL 2.2099 mL 4.4199 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2099 mL 11.0497 mL 22.0994 mL 55.2486 mL
5 mM 0.4420 mL 2.2099 mL 4.4199 mL 11.0497 mL
10 mM 0.2210 mL 1.1050 mL 2.2099 mL 5.5249 mL
15 mM 0.1473 mL 0.7366 mL 1.4733 mL 3.6832 mL
20 mM 0.1105 mL 0.5525 mL 1.1050 mL 2.7624 mL
25 mM 0.0884 mL 0.4420 mL 0.8840 mL 2.2099 mL
30 mM 0.0737 mL 0.3683 mL 0.7366 mL 1.8416 mL
40 mM 0.0552 mL 0.2762 mL 0.5525 mL 1.3812 mL
50 mM 0.0442 mL 0.2210 mL 0.4420 mL 1.1050 mL
60 mM 0.0368 mL 0.1842 mL 0.3683 mL 0.9208 mL
80 mM 0.0276 mL 0.1381 mL 0.2762 mL 0.6906 mL
100 mM 0.0221 mL 0.1105 mL 0.2210 mL 0.5525 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ABBV-712 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABBV-7122368945-27-9ABBV712ABBV 712JAKJanus kinaseTYK2 InhibitorAutoimmune RiseasesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ABBV-712
Cat. No.:
HY-156409
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.