Aberrant tau ligand 1

Cat. No.: HY-W453397 Purity: 99.33%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Aberrant tau ligand 1 is a ligand for tau proteins with abnormal forms. Aberrant tau ligand 1 can be used for synthesis of PROTAC aberrant Tau degrader QC-01-175 (HY-134850).

For research use only. We do not sell to patients.

Aberrant tau ligand 1 Chemical Structure

CAS No. : 1892461-96-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Aberrant tau ligand 1 is a ligand for tau proteins with abnormal forms. Aberrant tau ligand 1 can be used for synthesis of PROTAC aberrant Tau degrader QC-01-175 (HY-134850)^[1].

Molecular Weight

240.26

Formula

C₁₄H₁₂N₂O₂

CAS No.

1892461-96-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCC1=CC2=C(C=C1)C(C=NC=C3)=C3N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (52.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1622 mL	20.8108 mL	41.6216 mL
5 mM	0.8324 mL	4.1622 mL	8.3243 mL
10 mM	0.4162 mL	2.0811 mL	4.1622 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.33%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (248 KB) HNMR (251 KB) RP-HPLC (126 KB) LCMS (135 KB)

Handling Instructions (2659 KB)

References

[1]. Silva MC, et al., Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1622 mL	20.8108 mL	41.6216 mL	104.0539 mL
	5 mM	0.8324 mL	4.1622 mL	8.3243 mL	20.8108 mL
	10 mM	0.4162 mL	2.0811 mL	4.1622 mL	10.4054 mL
	15 mM	0.2775 mL	1.3874 mL	2.7748 mL	6.9369 mL
	20 mM	0.2081 mL	1.0405 mL	2.0811 mL	5.2027 mL
	25 mM	0.1665 mL	0.8324 mL	1.6649 mL	4.1622 mL
	30 mM	0.1387 mL	0.6937 mL	1.3874 mL	3.4685 mL
	40 mM	0.1041 mL	0.5203 mL	1.0405 mL	2.6013 mL
	50 mM	0.0832 mL	0.4162 mL	0.8324 mL	2.0811 mL