2. PROTAC Neuronal Signaling
  3. PROTACs Tau Protein
  4. QC-01–175

QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984)).

For research use only. We do not sell to patients.

QC-01–175 Chemical Structure

QC-01–175 Chemical Structure

CAS No. : 2267290-96-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 276 In-stock
Solution
10 mM * 1 mL in DMSO USD 276 In-stock
Solid
5 mg USD 200 In-stock
10 mg USD 320 In-stock
25 mg USD 620 In-stock
50 mg USD 980 In-stock
100 mg USD 1540 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

QC-01–175 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984))[1][2].

In Vitro

QC-01-175 (1-10 μM, 2-24 h) reduces the levels of pTau-S396 in SH-SY5Y cells induced by ALS SNs[2].
QC-01-175 (10 μM, 4 h) alleviates ALS SNs-induced mitochondrial fragmentation and increases in oxidative stress in SH-SY5Y cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

QC-01–175 Related Antibodies

Western Blot Analysis[2]

Cell Line: SH-SY5Y induced by ALS SNs
Concentration: 1, 10 μM
Incubation Time: 2, 4, 24 h
Result: Reduced pTau-S396 levels, restored after 24 hours.
Molecular Weight

626.66

Formula

C33H34N6O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC4=CC5=C(C=C4)C(C=NC=C6)=C6N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (199.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5958 mL 7.9788 mL 15.9576 mL
5 mM 0.3192 mL 1.5958 mL 3.1915 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5958 mL 7.9788 mL 15.9576 mL 39.8940 mL
5 mM 0.3192 mL 1.5958 mL 3.1915 mL 7.9788 mL
10 mM 0.1596 mL 0.7979 mL 1.5958 mL 3.9894 mL
15 mM 0.1064 mL 0.5319 mL 1.0638 mL 2.6596 mL
20 mM 0.0798 mL 0.3989 mL 0.7979 mL 1.9947 mL
25 mM 0.0638 mL 0.3192 mL 0.6383 mL 1.5958 mL
30 mM 0.0532 mL 0.2660 mL 0.5319 mL 1.3298 mL
40 mM 0.0399 mL 0.1995 mL 0.3989 mL 0.9974 mL
50 mM 0.0319 mL 0.1596 mL 0.3192 mL 0.7979 mL
60 mM 0.0266 mL 0.1330 mL 0.2660 mL 0.6649 mL
80 mM 0.0199 mL 0.0997 mL 0.1995 mL 0.4987 mL
100 mM 0.0160 mL 0.0798 mL 0.1596 mL 0.3989 mL
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QC-01–175 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QC-01–1752267290-96-8PROTACsTau ProteinFTDfrontotemporal dementia8330-8-RC1MGH2069-RC1CTR2-L17-RC2progressive supranuclear palsyAlzheimer’s diseaseADPSPTauopathyInhibitorinhibitorinhibit

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