Adenosine N1-oxide 

Adenosine N1-oxide is an oral active anti-inflammatory agent, and can be isolated from royal jelly. Adenosine N1-oxide promotes osteogenic and adipocyte differentiation^[1][2].

Adenosine N1-oxide )(1-40 μM, 24 h) inhibits TNF-α and IL-6 secretion by RAW264.7 cells stimulated with 2 µg/mL LPS (HY-D1056)^[2].
Adenosine N1-oxide )(20/100 μM, 30 mins) increases intracellular cAMP production in both peritoneal macrophages and RAW264.7 cells in a dose-dependent manner^[2].
Adenosine N1-oxide )(5-10 μM, 30 mins) increases the protein level of phosphorylation of Akt and GSK-3β in 2 µg/mL LPS (HY-D1056)-stimulated RAW264.7 cells^[2].
Adenosine N1-oxide )(2-10 μM, 6-7 days) promotes osteogenic and adipocyte differentiation in MC3T3-E1 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adenosine N1-oxide (oral administration, 135 mg/kg for three times) reduces the lethality caused by LPS (HY-D1056)-induced endotoxin shock in BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

283.24

C₁₀H₁₃N₅O₅

146-92-9

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=[N+]([O-])C=N3)O1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kohno K, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015;12(1):2. Published 2015 Jan 20.  [Content Brief]

  [2]. Ohashi E, et al. Adenosine N1-Oxide Exerts Anti-inflammatory Effects through the PI3K/Akt/GSK-3β Signaling Pathway and Promotes Osteogenic and Adipocyte Differentiation. Biol Pharm Bull. 2019;42(6):968-976.  [Content Brief]