2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. ADS032

ADS032 is a dual inhibitor of NLRP1 and NLRP3 that can rapidly, reversibly and stably inhibit inflammasome formation. ADS032 can reduce NLPR1 and NLRP3 activation of human macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduce NLRP3-induced ASC speck formation. ADS032 protected mice against the deadly influenza A virus, reducing inflammation in the lungs and improving survival. ADS032 inhibits Nigericin (HY-127019)-induced IL-1β secretion with IC50s of 94.6 μM (No wash out) and 354 μM (Wash out) respectively.

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ADS032 Chemical Structure

ADS032 Chemical Structure

CAS No. : 2757333-37-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 132 In-stock
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5 mg USD 120 In-stock
10 mg USD 205 In-stock
25 mg USD 410 In-stock
50 mg USD 700 In-stock
100 mg USD 1120 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

ADS032 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ADS032

View All NOD-like Receptor (NLR) Isoform Specific Products:

View All Isoforms
NLRP3 NLRP1 NOD1 NOD2

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Description

ADS032 is a dual inhibitor of NLRP1 and NLRP3 that can rapidly, reversibly and stably inhibit inflammasome formation. ADS032 can reduce NLPR1 and NLRP3 activation of human macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduce NLRP3-induced ASC speck formation. ADS032 protected mice against the deadly influenza A virus, reducing inflammation in the lungs and improving survival. ADS032 inhibits Nigericin (HY-127019)-induced IL-1β secretion with IC50s of 94.6 μM (No wash out) and 354 μM (Wash out) respectively[1].

IC50 & Target

NLRP1; NLRP3[1]
Molecular Weight

403.53

Formula

C22H29NO4S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(CCCC1=CC=C(C2=CC=C(S(=O)(N(CCC)CCC)=O)C=C2)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (247.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 12.5 mg/mL (30.98 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4781 mL 12.3907 mL 24.7813 mL
5 mM 0.4956 mL 2.4781 mL 4.9563 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.4781 mL 12.3907 mL 24.7813 mL 61.9533 mL
5 mM 0.4956 mL 2.4781 mL 4.9563 mL 12.3907 mL
10 mM 0.2478 mL 1.2391 mL 2.4781 mL 6.1953 mL
15 mM 0.1652 mL 0.8260 mL 1.6521 mL 4.1302 mL
20 mM 0.1239 mL 0.6195 mL 1.2391 mL 3.0977 mL
25 mM 0.0991 mL 0.4956 mL 0.9913 mL 2.4781 mL
30 mM 0.0826 mL 0.4130 mL 0.8260 mL 2.0651 mL
DMSO 40 mM 0.0620 mL 0.3098 mL 0.6195 mL 1.5488 mL
50 mM 0.0496 mL 0.2478 mL 0.4956 mL 1.2391 mL
60 mM 0.0413 mL 0.2065 mL 0.4130 mL 1.0326 mL
80 mM 0.0310 mL 0.1549 mL 0.3098 mL 0.7744 mL
100 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6195 mL
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ADS032 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADS0322757333-37-0ADS 032ADS-032NOD-like Receptor (NLR)NLRP1NLRP3drug targetsinflammasomeinflammationpulmonary inflammationInhibitorinhibitorinhibit

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