2. Immunology/Inflammation
  3. NOD-like Receptor (NLR) Interleukin Related
  4. ADS032

ADS032 is a sulfonylurea compound that is an NLRP1 and NLRP3 inflammasome inhibitor. ADS032 reduces the secretion of inflammatory factors and inhibits the oligomerization of ASC. ADS032 has anti-inflammatory effects in a variety of inflammatory models and can be used in the study of inflammatory diseases.

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ADS032 Chemical Structure

ADS032 Chemical Structure

CAS No. : 2757333-37-0

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Based on 1 publication(s) in Google Scholar

ADS032 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ADS032

View All NOD-like Receptor (NLR) Isoform Specific Products:

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NLRP3 NLRP1 NOD1 NOD2

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

ADS032 is a sulfonylurea compound that is an NLRP1 and NLRP3 inflammasome inhibitor. ADS032 reduces the secretion of inflammatory factors and inhibits the oligomerization of ASC. ADS032 has anti-inflammatory effects in a variety of inflammatory models and can be used in the study of inflammatory diseases[1].

IC50 & Target[1]

NLRP1

 

NLRP3

 

In Vitro

ADS032 (20-350 μM; 60 min) decreases NLRP3-mediated IL-1β secretion and ASC speck formation in human macrophages treated with Nigeriomycin (HY-127019) and silica[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ADS032 Related Antibodies
In Vivo

ADS032 (200 mg/kg; intraperitoneal injection; single dose) has a ameliorative effect in LPS (HY-D1056)-induced mouse inflammation model[1].
ADS032 (20 mg/kg; nasal administration; 2-3 doses) protects mice from severe IAV disease and reduces lung inflammation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS (HY-D1056) treated C57BL/6 mice [1]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection (i.p.); single dose
Result: Significantly reduced levels of circulating inflammatory cytokines IL-1β, TNF-α and IFN-γ, while IL-10 was not affected.
Animal Model: HKx31 (an IAV relative to PR8) treated C57BL/6 mice[1]
Dosage: 20 mg/kg
Administration: Nasal administration; 2-3 doses: days 1, 3 and 5 or days 3 and 5 post-IAV infection (day 0)
Result: Reduced the weight loss and mortality of mice.
Did not induce any noticeable pulmonary inflammation itself.
Reduced IL-6, TNF-a and MCP-1 BALF concentrations.
Reduced total cellular infiltrates in the lungs, characterised by significantly reduced neutrophils, macrophages and dendritic cells.
Molecular Weight

403.53

Formula

C22H29NO4S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(CCCC1=CC=C(C2=CC=C(S(=O)(N(CCC)CCC)=O)C=C2)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (247.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 12.5 mg/mL (30.98 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4781 mL 12.3907 mL 24.7813 mL
5 mM 0.4956 mL 2.4781 mL 4.9563 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.4781 mL 12.3907 mL 24.7813 mL 61.9533 mL
5 mM 0.4956 mL 2.4781 mL 4.9563 mL 12.3907 mL
10 mM 0.2478 mL 1.2391 mL 2.4781 mL 6.1953 mL
15 mM 0.1652 mL 0.8260 mL 1.6521 mL 4.1302 mL
20 mM 0.1239 mL 0.6195 mL 1.2391 mL 3.0977 mL
25 mM 0.0991 mL 0.4956 mL 0.9913 mL 2.4781 mL
30 mM 0.0826 mL 0.4130 mL 0.8260 mL 2.0651 mL
DMSO 40 mM 0.0620 mL 0.3098 mL 0.6195 mL 1.5488 mL
50 mM 0.0496 mL 0.2478 mL 0.4956 mL 1.2391 mL
60 mM 0.0413 mL 0.2065 mL 0.4130 mL 1.0326 mL
80 mM 0.0310 mL 0.1549 mL 0.3098 mL 0.7744 mL
100 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6195 mL
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ADS032 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADS0322757333-37-0ADS 032ADS-032NOD-like Receptor (NLR)Interleukin RelatedILMacrophagesInflammation modelInhibitorinhibitorinhibit

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