2. Apoptosis
  3. Apoptosis
  4. Agelastatin A

Agelastatin A  (Synonyms: (-)-Agelastatin A; AglA)

Cat. No.: HY-125132
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Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity.

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Agelastatin A Chemical Structure

Agelastatin A Chemical Structure

CAS No. : 152406-28-5

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Agelastatin A Related Antibodies

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Description

Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity[1].

In Vitro

Agelastatin A(0-2 μM, 48 h) has IC50 values of 67 nM, 708 nM, 1.05 μM, 278 nM and 1.11 μM on U-937, HeLa, A549, BT549 and IMR90 cells, respectively[1].
Agelastatin A(0-1 μM, 48 h) has IC50 values of 20, 74, 20, 138 and 187 nM on CEM, Jurkat, Daudi, HL-60 and CA46 cells, respectively[1].
Agelastatin A (0-150 nM, 16 h) can dose-dependently induce U-937 cell cycle arrest at G2/M[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Agelastatin A Related Antibodies
In Vivo

The pharmacokinetic parameters of Agelastatin A(1a) a single 2.5 mg/kg dose in mice[2].

Parameter/td> intravenous (IV) intraperitoneal (IP)
ACU 1742 2946
Cmax 4.5 μM 1.65 μM
Tmax 2 min 30 min
t1/2 4 min 1 h

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

341.16

Formula

C12H13BrN4O3
CAS No.
SMILES

BrC(N1[C@@]2([H])[C@](N3)([H])[C@@]4([H])[C@@](C2)(N(C(N4)=O)C)O)=CC=C1C3=O
Structure Classification
Initial Source

A. dendromorpha
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Agelastatin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Agelastatin A152406-28-5(-)-Agelastatin A AglAApoptosisAgelas dendromorphaapoptosisantitumorInhibitorinhibitorinhibit

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