AKT Kinase Inhibitor hydrochloride

Name: AKT Kinase Inhibitor hydrochloride
Brand: MedChemExpress
SKU: HY-10249D
Rating: 5.0 (15 reviews)

Cat. No.: HY-10249D Purity: 99.39%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity. AKT Kinase Inhibitor (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

AKT Kinase Inhibitor hydrochloride Chemical Structure

CAS No. : 3026697-00-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 462	Get quote	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 462	Get quote	Estimated Time of Arrival: December 31
Solid
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 15 publication(s) in Google Scholar

Other Forms of AKT Kinase Inhibitor hydrochloride:

AKT Kinase Inhibitor In-stock

14 Publications Citing Use of MCE AKT Kinase Inhibitor hydrochloride

: AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Mediat Inflamm. 2020 Jun 24;2020:3621261. [Abstract]; After treatment with HY-10249A, the expression of p-IκB-α and p-NF-κB p65 is reduced.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity^[1]. AKT Kinase Inhibitor (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

393.83

Formula

C₁₆H₂₀ClN₇O₃

CAS No.

3026697-00-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

OCC#CC1=NC=C(C2=C1N=C(N2CC)C3=NON=C3N)OCCCN.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 20 mg/mL (50.78 mM; Need ultrasonic)

DMSO : 3.33 mg/mL (8.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5392 mL	12.6958 mL	25.3917 mL
5 mM	0.5078 mL	2.5392 mL	5.0783 mL
10 mM	0.2539 mL	1.2696 mL	2.5392 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.39%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (251 KB) HNMR (484 KB) RP-HPLC (205 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.5392 mL	12.6958 mL	25.3917 mL	63.4792 mL
DMSO / H₂O	5 mM	0.5078 mL	2.5392 mL	5.0783 mL	12.6958 mL
H₂O	10 mM	0.2539 mL	1.2696 mL	2.5392 mL	6.3479 mL
	15 mM	0.1693 mL	0.8464 mL	1.6928 mL	4.2319 mL
	20 mM	0.1270 mL	0.6348 mL	1.2696 mL	3.1740 mL
	25 mM	0.1016 mL	0.5078 mL	1.0157 mL	2.5392 mL
	30 mM	0.0846 mL	0.4232 mL	0.8464 mL	2.1160 mL
	40 mM	0.0635 mL	0.3174 mL	0.6348 mL	1.5870 mL
	50 mM	0.0508 mL	0.2539 mL	0.5078 mL	1.2696 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.