2. PI3K/Akt/mTOR Apoptosis
  3. Akt Caspase
  4. Akt1/Akt2-IN-2

Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells.

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Akt1/Akt2-IN-2 Chemical Structure

Akt1/Akt2-IN-2 Chemical Structure

CAS No. : 612847-42-4

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Based on 1 publication(s) in Google Scholar

Akt1/Akt2-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All Akt Isoform Specific Products:

View All Isoforms
Akt Akt1 Akt2 Akt3

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

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Description

Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].

IC50 & Target[1]

Akt1

138 nM (IC50)

Akt2

212 nM (IC50)

Akt3

7.2 mM (IC50)

Caspase-3

 

In Vitro

Akt1/Akt2-IN-2 (compound 7) has cytotoxicity against LnCaP, HT29, MCF7, and A2780 cells[1].
Akt1/Akt2-IN-2 (2 μM, 4 μM) induces caspase-3 activity up to 3 or 6.6 fold increases in LnCaP cells, at 2 μM and 4 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Akt1/Akt2-IN-2 Related Antibodies
Molecular Weight

653.82

Formula

C40H43N7O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C2N=C(C3=CC=CC=C3)C(C4=CC=C(CN5CCC(N6C7=CC=CC=C7NC6=O)CC5)C=C4)=NC2=C1)NCCN(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 18 mg/mL (27.53 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5295 mL 7.6474 mL 15.2947 mL
5 mM 0.3059 mL 1.5295 mL 3.0589 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.5295 mL 7.6474 mL 15.2947 mL 38.2368 mL
5 mM 0.3059 mL 1.5295 mL 3.0589 mL 7.6474 mL
10 mM 0.1529 mL 0.7647 mL 1.5295 mL 3.8237 mL
15 mM 0.1020 mL 0.5098 mL 1.0196 mL 2.5491 mL
20 mM 0.0765 mL 0.3824 mL 0.7647 mL 1.9118 mL
25 mM 0.0612 mL 0.3059 mL 0.6118 mL 1.5295 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Akt1/Akt2-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Akt1/Akt2-IN-2612847-42-4AktCaspasePKBProtein kinase BInhibitorinhibitorinhibit

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