2. Anti-infection Metabolic Enzyme/Protease
  3. Parasite Oxidative Phosphorylation
  4. Amoscanate

Amoscanate  (Synonyms: CGP4540)

Cat. No.: HY-129051 Purity: 99.45%
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Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma.

For research use only. We do not sell to patients.

Amoscanate Chemical Structure

Amoscanate Chemical Structure

CAS No. : 26328-53-0

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10 mg USD 250 In-stock
25 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

Amoscanate Related Antibodies

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Description

Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].

IC50 & Target

Schistosome

 

In Vivo

Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain[1].
Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1].
Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1].
Amoscanate elicits massive ultrastructural damage in ependymal cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 500 mg/kg
Administration: P.o.; 10 days
Result: Destructed ependyma and periventricular brain.
Animal Model: Sprague-Dawley rats[1]
Dosage: 250 and 500 mg/kg
Administration: P.o.; 28 days
Result: Elicited necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum.
Animal Model: Sprague-Dawley rats[1]
Dosage: 25~500 mg/kg
Administration: P.o.; 20 days
Result: Elicited progressive necrosis of ependymal.
Molecular Weight

271.29

Formula

C13H9N3O2S
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=[N+]([O-])C(C=C1)=CC=C1NC2=CC=C(C=C2)N=C=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (184.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6861 mL 18.4305 mL 36.8609 mL
5 mM 0.7372 mL 3.6861 mL 7.3722 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6861 mL 18.4305 mL 36.8609 mL 92.1523 mL
5 mM 0.7372 mL 3.6861 mL 7.3722 mL 18.4305 mL
10 mM 0.3686 mL 1.8430 mL 3.6861 mL 9.2152 mL
15 mM 0.2457 mL 1.2287 mL 2.4574 mL 6.1435 mL
20 mM 0.1843 mL 0.9215 mL 1.8430 mL 4.6076 mL
25 mM 0.1474 mL 0.7372 mL 1.4744 mL 3.6861 mL
30 mM 0.1229 mL 0.6143 mL 1.2287 mL 3.0717 mL
40 mM 0.0922 mL 0.4608 mL 0.9215 mL 2.3038 mL
50 mM 0.0737 mL 0.3686 mL 0.7372 mL 1.8430 mL
60 mM 0.0614 mL 0.3072 mL 0.6143 mL 1.5359 mL
80 mM 0.0461 mL 0.2304 mL 0.4608 mL 1.1519 mL
100 mM 0.0369 mL 0.1843 mL 0.3686 mL 0.9215 mL
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Amoscanate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amoscanate26328-53-0CGP4540CGP 4540CGP-4540ParasiteOxidative Phosphorylationanti-schistosomalisothiocyanateuncoupleroxidativephosphorylationpotentlyrodentependymalInhibitorinhibitorinhibit

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