2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. AMP-PCP disodium

AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90.

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AMP-PCP disodium Chemical Structure

AMP-PCP disodium Chemical Structure

CAS No. : 7414-56-4

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1 mg USD 80 In-stock
5 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of AMP-PCP disodium:

AMP-PCP disodium Related Antibodies

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1].

IC50 & Target[1]

HSP90

3.8 μM (Kd)

In Vitro

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMP-PCP disodium Related Antibodies
Molecular Weight

549.17

Formula

C11H16N5Na2O12P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O[Na])=O)(O[Na])=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (182.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8209 mL 9.1046 mL 18.2093 mL
5 mM 0.3642 mL 1.8209 mL 3.6419 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (91.05 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.29%

COA (249 KB) HNMR (281 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8209 mL 9.1046 mL 18.2093 mL 45.5232 mL
5 mM 0.3642 mL 1.8209 mL 3.6419 mL 9.1046 mL
10 mM 0.1821 mL 0.9105 mL 1.8209 mL 4.5523 mL
15 mM 0.1214 mL 0.6070 mL 1.2140 mL 3.0349 mL
20 mM 0.0910 mL 0.4552 mL 0.9105 mL 2.2762 mL
25 mM 0.0728 mL 0.3642 mL 0.7284 mL 1.8209 mL
30 mM 0.0607 mL 0.3035 mL 0.6070 mL 1.5174 mL
40 mM 0.0455 mL 0.2276 mL 0.4552 mL 1.1381 mL
50 mM 0.0364 mL 0.1821 mL 0.3642 mL 0.9105 mL
60 mM 0.0303 mL 0.1517 mL 0.3035 mL 0.7587 mL
80 mM 0.0228 mL 0.1138 mL 0.2276 mL 0.5690 mL
100 mM 0.0182 mL 0.0910 mL 0.1821 mL 0.4552 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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AMP-PCP disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMP-PCP disodium7414-56-4HSPHeat shock proteinsATPhomodimerHsp90residuesconformationalN-terminalATPaseInhibitorinhibitorinhibit

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